K2389

Kainic acid monohydrate

≥98% (HPLC), from Digenea simplex

• 동의어(들): 2-Carboxy-3-carboxymethyl-4-isopropenylpyrrolidine
• 실험식(Hill 표기법): C₁₀H₁₅NO₄ · H₂O
• CAS Number: 58002-62-3
• Molecular Weight: 231.25
• MDL number: MFCD00150833
• UNSPSC 코드: 12352106
• PubChem Substance ID: 24724520
• NACRES: NA.77

속성

• 생물학적 소스: Digenea simplex
• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white
• solubility: H₂O: >10 mg/mL
• 저장 온도: 2-8°C
• SMILES string: O.CC(=C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O
• InChI: 1S/C10H15NO4.H2O/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13;/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15);1H2/t6-,7+,9-;/m0./s1
• InChI key: FZNZRJRSYLQHLT-SLGZUKMRSA-N

설명

애플리케이션

Kainic acid monohydrate has been used:

• As a convulsant to induce epileptogenesis and epilepsy in mice.
• To stimulate in vitro excitotoxic trauma in spiral ganglion neurons on inner hair cells.
• To induce seizures in rat model.
• To induce status epilepticus in adult male Wistar rats.

생화학적/생리학적 작용

Ionotropic glutamate receptors form ion channels, and conduct Na⁺ and K⁺ fluxes. The receptors possess an agonist binding site and it encounters a conformational change upon agonist binding to it. Kainate gated channels participate in glutamate-induced excitatory postsynaptic neuronal potential.

Kainic acid monohydrate is an agonist at the kainate class of ionotropic glutamate receptors, which induces seizures and neurodegeneration in vivo and is used to induce experimental epilepsy in rodents and study the mechanisms of excitation-induced neuronal apoptosis.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)