H8653
(±)-7-Hydroxy-2-(di-n-propylamino)tetralin hydrobromide
동의어(들):
(±)-2-Dipropylamino-7-hydroxy-1,2,3,4-tetrahydronaphthalene hydrobromide, (±)-7-Hydroxy-DPAT hydrobromide, (±)-7-OH-DPAT hydrobromide
로그인조직 및 계약 가격 보기
모든 사진(2)
About This Item
실험식(Hill 표기법):
C16H25NO · HBr
CAS Number:
Molecular Weight:
328.29
MDL number:
UNSPSC 코드:
12352200
PubChem Substance ID:
NACRES:
NA.32
추천 제품
solubility
H2O: >15 mg/mL
Quality Level
저장 온도
2-8°C
SMILES string
Br.CCCN(CCC)C1CCc2ccc(O)cc2C1
InChI
1S/C16H25NO.BrH/c1-3-9-17(10-4-2)15-7-5-13-6-8-16(18)12-14(13)11-15;/h6,8,12,15,18H,3-5,7,9-11H2,1-2H3;1H
InChI key
ODNDMTWHRYECKX-UHFFFAOYSA-N
유전자 정보
human ... DRD3(1814)
생화학적/생리학적 작용
(±)-7-Hydroxy-2-(di-n-propylamino)tetralin hydrobromide is a selective D3 dopamine receptor agonist (Kd <1nM); has much weaker affinity for other dopamine receptor subtypes.
신호어
Warning
유해 및 위험 성명서
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
표적 기관
Respiratory system
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
dust mask type N95 (US), Eyeshields, Gloves
F N Dastur et al.
European journal of pharmacology, 382(2), 53-67 (1999-10-21)
The dopamine D(1) receptor agonist, R(+)-6-chloro-7, 8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide (SKF 81297), the dopamine D(2)/D(3) receptor agonist, trans-(-)-4aR-4,4a,5,6,7,8,8a,9-octahydro-5-propyl-1H-pyrazolo[3, 4-g]quinoline hydrochloride (quinpirole), and the dopamine D(3) receptor agonist, (+/-)-7-hydroxy-dipropylaminotetralin hydrobromide (7-OH-DPAT) all reduced the frequency of isolation-induced infant rat ultrasonic vocalizations and lowered
Zofia Rogóz et al.
Polish journal of pharmacology, 55(3), 449-454 (2003-09-25)
The aim of the present study was to examine a potential anxiolytic-like action of (+)-7-hydroxy-2-(di-n-propylamino)tetralin hydrobromide (7-OH-DPAT), a preferential dopamine D(3) receptor agonist, and (N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]-2-naphthylcarboxamide (BP 897), partial dopamine D(3) receptor agonist. Diazepam was used as a reference compound. The
S B Caine et al.
The Journal of pharmacology and experimental therapeutics, 291(1), 353-360 (1999-09-22)
The reinforcing effects of D(1-like) and D(2-like) agonists, and their capacity to modify cocaine self-administration, were compared in rats with extensive cocaine self-administration experience. Cocaine (0.01-1.0 mg i.v.) dose-dependently maintained responding under a fixed ratio (FR) 5 schedule of reinforcement
J Maj et al.
European journal of pharmacology, 351(1), 31-37 (1998-08-11)
Previous studies have indicated that antidepressant drugs displaying different pharmacological profiles, administered repeatedly, increase the locomotor hyperactivity induced by various dopaminomimetics, among others by quinpirole. As this drug, according to a recent study, shows high affinity not only for dopamine
David Kabelik et al.
Neuropharmacology, 58(1), 117-125 (2009-06-23)
Recent experiments demonstrate that aggressive competition for potential mates involves different neural mechanisms than does territorial, resident-intruder aggression. However, despite the obvious importance of mate competition aggression, we know little about its regulation. Immediate early gene experiments show that in
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