H8041

IL-23 human

HumanKine^®, recombinant, Xeno-free, >95% (SDS-PAGE), suitable for cell culture

• 동의어(들): Human IL-23, IL-23 Cytokine, Interleukin 23
• UNSPSC 코드: 12352202
• NACRES: NA.77

속성

• 제품명: Interleukin-23 human, IL-23, recombinant, expressed in HEK 293 cells, HumanKine^®, suitable for cell culture
• 생물학적 소스: human
• Quality Level: 100
• 재조합: expressed in HEK 293 cells
• 분석: ≥95% (SDS-PAGE)
• 양식: lyophilized powder
• 효능: ≤2 ng/mL EC₅₀
• 품질: endotoxin tested
• 분자량: dimer 55 kDa (glycosylated)
• 포장: pkg of 5X10 μg; pkg of 10 μg; pkg of 5 μg
• 기술: cell culture | mammalian: suitable
• 불순물: ≤1EU/mg
• UniProt 수납 번호: Q9NPF7
• 저장 온도: −20°C
• 유전자 정보: human ... IL23A(51561)

설명

일반 설명

HumanKine interleukin-23 (IL-23) is expressed as a heterodimeric 55 kDa cytokine composed of two glycosylated and disulfide linked subunits (p40 cystine linked to p19). Production in human HEK 293 cells offers authentic glycosylation. Cytokines produced in Sf9 or Sf21 cells have post-translational modifications, which are not human-like.

Interleukin-23 (IL-23) is a pro-inflammatory cytokine. It is mostly synthesized by activated dendritic cells and macrophages. It is a 20.7kDa protein with 189 amino acids. IL-23 is mostly expressed on activated/memory T cells and natural killer (NK) cells. This gene is located on human chromosome 12q13.3.

생화학적/생리학적 작용

Interleukin-23 (IL-23) plays a major role in cutaneous immune-mediated inflammatory diseases like psoriasis, allergic contact dermatitis and atopic dermatitis. It is involved in cellular immunity, driving the expansion, stabilization and survival of Th17 cells.

분석 메모

The specific activity was determined by the dose-dependent secretion of h-IFN-γ or IL-8 from human PBMC.

법적 정보

HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1