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H3884

Sigma-Aldrich

Hyaluronidase from bovine testes

Type IV-S, lyophilized powder (essentially salt-free), 750-3000 units/mg solid

동의어(들):

Hyaluronate 4-glycanohydrolase, Hyaluronoglucosaminidase

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모든 사진(5)

About This Item

CAS Number:
37326-33-3
효소 위원회 번호:
3.2.1.35 (BRENDA, IUBMB)
EC Number:
253-464-3
MDL number:
MFCD00131351
UNSPSC 코드:
12352204
NACRES:
NA.54

생물학적 소스

bovine testis

Quality Level

200

결합

conjugate (Glucosaminoglycan)

유형

Type IV-S

형태

lyophilized powder (essentially salt-free)

특이 활성도

750-3000 units/mg solid

분자량

~55 kDa (four subunits of 14 kDa each)

UniProt 수납 번호

Q5E985
Q8SQG8

응용 분야

diagnostic assay manufacturing

관련 질환(들)

cancer

저장 온도

−20°C

유전자 정보

cow ... HYAL1(515397) , HYAL2(281838)

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관련 카테고리

생화학적/생리학적 작용

Hyaluronidase degrades hyaluronan and has been found to be inappropriately regulated during cancer progression.
These enzymes randomly cleave β-N-acetylhexosamine-[1→4] glycosidic bonds in hyaluronic acid, chondroitin, and chondroitin sulfates.

단위 정의

One unit will degrade 0.75 μg of the polysaccharide hyaluronic acid per minute at pH 5.35 at 37 ºC (as measured by turbidimetric absorbance (λ: 600nm) when complexed with BSA after 45 minutes).

기타 정보

View more information on enzymes for complex carbohydrate analysis at www.sigma-aldrich.com/enzymeexplorer

픽토그램

Health hazard
GHS08

신호어

Danger

유해 및 위험 성명서

H334

예방조치 성명서

P261 - P284 - P501

Hazard Classifications

Resp. Sens. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)

시험 성적서(COA)

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이 제품을 이미 가지고 계십니까?

문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Claire M McLeod et al.
Scientific reports, 6, 38852-38852 (2016-12-13)
Extracellular matrix dynamics are key to tissue morphogenesis, homeostasis, injury, and repair. The spatiotemporal organization of this matrix has profound biological implications, but is challenging to monitor using standard techniques. Here, we address these challenges by using noncanonical amino acid
Matthew R Kent et al.
Neural regeneration research, 16(2), 367-374 (2020-08-30)
A potential treatment for retinal diseases is to induce an endogenous Müller glia (MG)-derived regenerative response to replace damaged neurons. In contrast to mammalian MG, zebrafish MG are capable of mediating spontaneous regeneration. We seek to define the mechanisms that
Alicia Santos Savio et al.
BMC musculoskeletal disorders, 16, 51-51 (2015-04-17)
Pro-inflammatory cytokines are directly implicated in the pathogenesis of Rheumatoid arthritis (RA). Variable clinical response to cytokine targeted therapies as TNFalpha and IL-6, strongly highlights the heterogeneity of inflammatory process in RA. Another cytokine, IL-15 has also been related to
Carlos Henríquez-Olguín et al.
Redox biology, 24, 101188-101188 (2019-04-09)
Reactive oxygen species (ROS) have been proposed as signaling molecules mediating exercise training adaptation, but the ROS source has remained unclear. This study aimed to investigate if increased NADPH oxidase (NOX)2-dependent activity during exercise is required for long-term high-intensity interval
Isabel N Tromp et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 39(9), 1955-1964 (2020-11-23)
It has been suggested that curvature progression in adolescent idiopathic scoliosis occurs through irreversible changes in the intervertebral discs. Strains of mice have been identified who differ in their disc wedging response upon extended asymmetrical compression. Annulus fibrosus (AF) tissue
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문서

Carbohydrate Analysis

A key resource feature at our Enzyme Explorer section of biochemicals is "Enzymes for Carbohydrate Analysis and Digestion." Offering kits, reagents, analysis, lists of enzymes related to PTM and carbohydrate metabolism.

Glycosaminoglycan Sulfation and Signaling

Glycosaminoglycans are large linear polysaccharides constructed of repeating disaccharide units.

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