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Merck
모든 사진(2)

Key Documents

G8134

Sigma-Aldrich

Gallamine triethiodide

≥98% (TLC), powder, muscarinic receptor antagonist

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About This Item

실험식(Hill 표기법):
C30H60I3N3O3
CAS Number:
Molecular Weight:
891.53
EC Number:
MDL number:
UNSPSC 코드:
12352116
PubChem Substance ID:
NACRES:
NA.77

분석

≥98% (TLC)

형태

powder

mp

235 °C (dec.) (lit.)

solubility

H2O: 100 mg/mL
ethanol: soluble

저장 온도

2-8°C

SMILES string

[I-].[I-].[I-].CC[N+](CC)(CC)CCOc1cccc(OCC[N+](CC)(CC)CC)c1OCC[N+](CC)(CC)CC

InChI

1S/C30H60N3O3.3HI/c1-10-31(11-2,12-3)22-25-34-28-20-19-21-29(35-26-23-32(13-4,14-5)15-6)30(28)36-27-24-33(16-7,17-8)18-9;;;/h19-21H,10-18,22-27H2,1-9H3;3*1H/q+3;;;/p-3

InChI key

REEUVFCVXKWOFE-UHFFFAOYSA-K

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애플리케이션

Gallamine triethiodide has been used:
  • as a relaxant for measuring spinal trigeminal nucleus recordings from single neurons.
  • as an antagonist in neuroblastoma cells as M2 receptor
  • to reduce eye movement during retinal surgery in rat

생화학적/생리학적 작용

Gallamine triethiodide has anti-muscarinic effect. It is a competitive antagonist for the muscarinic receptor. Gallamine is regarded as neuromuscular blocking agent.
Muscle relaxant; allosteric muscarinic receptor antagonist with an order of potency of M2 > M1 = M4 > M3 = M5. Ligand for the peripheral anionic binding site of acetylcholinesterase.

특징 및 장점

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

주의사항

Hygroscopic

픽토그램

Exclamation mark

신호어

Warning

유해 및 위험 성명서

예방조치 성명서

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

개인 보호 장비

dust mask type N95 (US), Eyeshields, Gloves


시험 성적서(COA)

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이 제품을 이미 가지고 계십니까?

문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Sandrine B Daval et al.
Molecular pharmacology, 84(1), 71-85 (2013-04-23)
Bitopic binding properties apply to a variety of muscarinic compounds that span and simultaneously bind to both the orthosteric and allosteric receptor sites. We provide evidence that fluorescent pirenzepine derivatives, with the M1 antagonist fused to the boron-dipyrromethene [Bodipy (558/568)]
Paul W Elsinghorst et al.
Journal of medicinal chemistry, 50(23), 5685-5695 (2007-10-20)
Gallamine and tacrine are allosteric antagonists at muscarinic M2 acetylcholine receptors and inhibitors of acetylcholinesterase. At both acetylcholine-binding proteins, gallamine and tacrine are known to occupy two different binding sites: in M2 receptors within the allosteric binding area and in
The inhibitory effect of gallamine on muscarinic receptors
Clark AL and Mitchelson F
British Journal of Pharmacology, 58(3), 323-331 (1976)
Dar'ya S Redka et al.
Molecular pharmacology, 74(3), 834-843 (2008-06-17)
The M(2) muscarinic receptor has two topographically distinct sites: the orthosteric site and an allosteric site recognized by compounds such as gallamine. It also can exhibit cooperative effects in the binding of orthosteric ligands, presumably to the orthosteric sites within
Transcriptional response to muscarinic acetylcholine receptor stimulation: regulation of Egr-1 biosynthesis by ERK, Elk-1, MKP-1, and calcineurin in carbachol-stimulated human neuroblastoma cells
Rossler O, et al.
Archives of Biochemistry and Biophysics, 470(1), 93-102 (2008)

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