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F9911

Sigma-Aldrich

Fibronectin Proteolytic Fragment from human plasma

lyophilized powder, 30 kDa

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모든 사진(2)

About This Item

UNSPSC 코드:
12352202
eCl@ss:
42020141
NACRES:
NA.75

생물학적 소스

human plasma

Quality Level

200

분석

>90% (SDS-PAGE)

양식

lyophilized powder

분자량

30 kDa

포장

pkg of 0.5 mg

기술

cell culture | mammalian: suitable

불순물

HIV and HBsAg, source material tested negative
 Small proteolytic fragments, may contain traces

solubility

water: soluble >0.5 mg/mL, clear to slightly hazy, colorless

UniProt 수납 번호

P02751

배송 상태

ambient

저장 온도

−20°C

유전자 정보

human ... FN1(2335)

일반 설명

Fibronectin 1 is a glycoprotein of the extracellular matrix that is coded by FN1 gene. It is expressed in the plasma and at the cell surface. FN1 is mapped to human chromosome 2q35. Proteolytic fragments of fibronectin has a cell binding domain.

애플리케이션

Fibronectin proteolytic fragment has been used in solid phase binding assay.

생화학적/생리학적 작용

Fibronectin participates in cell adhesion, growth, migration, wound healing, blood coagulation and metastasis. Mutations in FN1 results in glomerulopathy. It plays an important role in cell attachment and spreading, control of cell cytoskeleton, morphology and differentiation. FN1 is also involved in extracellular matrix formation, hemostasis and thrombosis. Proteolytic fragments of fibronectin plays a vital role in mononuclear phagocyte function.

주의사항

The product should be stored at -20°C.

제조 메모

This product is lyophilized from phosphate buffered saline with sucrose as a cryoprotectant. The source material has tested negative for antibody to HIV, HCN, and HBsAg. It is soluble in water at 0.5 mg/mL and yields a clear to slightly hazy solution.

픽토그램

Exclamation mark
GHS07

신호어

Warning

유해 및 위험 성명서

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

표적 기관

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

가장 최신 버전 중 하나를 선택하세요:

시험 성적서(COA)

Lot/Batch Number
069M4158V
11181147
068M4107V
11180231
037M4175V

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COA 검색

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Arg-Gly-Asp ≥97% (TLC)

Sigma-Aldrich

A8052

Arg-Gly-Asp

Fibronectin human plasma lyophilized powder, BioReagent, suitable for cell culture, ≥95% (SDS-PAGE)

Sigma-Aldrich

F1056

Fibronectin human plasma

Fibronectin bovine plasma solution, sterile-filtered, BioReagent, suitable for cell culture

Sigma-Aldrich

F1141

Fibronectin bovine plasma

S Huff et al.
The Journal of biological chemistry, 269(22), 15563-15570 (1994-06-03)
The N-terminal 29-kDa fragment of fibronectin (Fn29K) contains five type I "finger" modules. It binds to heparin, fibrin, and bacteria and is involved in fibronectin (Fn) matrix assembly. Binding to Staphylococcus aureus involves a cell wall-associated protein that contains approximately
Fibronectin in Health and Disease (2018)
Maryada Sharma et al.
PloS one, 8(7), e69343-e69343 (2013-08-13)
Fibrosis is characterized by excessive accumulation of scar tissue as a result of exaggerated deposition of extracellular matrix (ECM), leading to tissue contraction and impaired function of the organ. Fibronectin (Fn) is an essential component of the ECM, and plays
E Nègre et al.
The Journal of biological chemistry, 269(35), 22039-22045 (1994-09-02)
A 30-kDa proteolytic fragment from the gelatin/collagen-binding domain of fibronectin is a potent inhibitor of fibronectin binding to Candida albicans, with a molar inhibition constant equal to that of intact fibronectin. Recombinant and proteolytic fragments from the cell-, the fibrin
Ming Liu et al.
Scientific reports, 5, 14449-14449 (2015-09-25)
Bacterial adhesins play a pivotal role in the tight bacteria-host cells attachment to initiate the downstream processes and bacterial infection of hosts. In this study, we identified a novel adhesin, VpadF in V. parahaemolyticus. Deletion of VpadF in V. parahaemolyticus
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문서

Extracellular Matrix Proteins and Tools for Cell Culture Optimization

Extracellular matrix proteins such as laminin, collagen, and fibronectin can be used as cell attachment substrates in cell culture.

프로토콜

Fibronectin Coating Protocol

Dilute fibronectin to the desired concentration. Optimum conditions for attachment are dependent on cell type and application. The typical coating concentration is 1 – 5 ug/cm2.Fibronectin coating protocol, products, and FAQs at sigmaaldrich.com

Fibronectin Coating Protocol

Dilute fibronectin to the desired concentration. Optimum conditions for attachment are dependent on cell type and application. The typical coating concentration is 1 – 5 ug/cm2.Fibronectin coating protocol, products, and FAQs.

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