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Merck
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Key Documents

F5305

Sigma-Aldrich

Monoclonal Anti-Fibroblast Growth Factor-Basic antibody produced in mouse

clone 10060, purified immunoglobulin, lyophilized powder

동의어(들):

Anti-FGF2

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About This Item

MDL number:
UNSPSC 코드:
51111800
NACRES:
NA.41

생물학적 소스

mouse

Quality Level

결합

unconjugated

항체 형태

purified immunoglobulin

항체 생산 유형

primary antibodies

클론

10060, monoclonal

형태

lyophilized powder

종 반응성

human

기술

capture ELISA: 2-8 μg/mL

동형

IgG2a

UniProt 수납 번호

저장 온도

−20°C

유전자 정보

human ... FGF2(2247)

유사한 제품을 찾으십니까? 방문 제품 비교 안내

일반 설명

Fibroblast Growth Factor Basic (also known as bFGF) is a pleotropic cytokine that that is a potent mitogenic factor. On binding to its cognate receptor tyrosine kinase, FGFR, bFGF is capable of activation of pathways such as MAPK and PI3K and produce cellular effects in varied cell types. Fibroblast Growth Factor-basic is repoted to induce proliferation of fibroblasts, differentiation, wound healing and regeneration, limb formation, tissue remodelling and angiogenesis. The role of bFGF in chondrocyte proliferation and repair has established the role of bFGF in maintaining cartilage and intervertebral disc homeostasis. Along with VEGF, bFGF is important in angiogenesis and tumorigenesis in response to inflammatory cytokines
Monoclonal Anti-Fibroblast Growth Factor Basic recognizes human Fibroblast Growth Factor Basic. It also recognizes bovine bFGF. It shows 0.2% cross-reactivity with bovine FGF acidic. It does not react with human FGF acidic, FGF-4, -6 or -7.

면역원

purified, E. coli-derived recombinant human fibroblast growth factor basic.

애플리케이션

Monoclonal Anti-Fibroblast Growth Factor Basic may be used as capture antibody in ELISA at a recommended concentration range of 2-8 μg/ml.

물리적 형태

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

13 - Non Combustible Solids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)


시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

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문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

H Schmal et al.
Cytotherapy, 9(2), 184-193 (2007-04-25)
The possible functional role of basic fibroblast growth factor (bFGF) in regulating the mitotic and metabolic activity of primary human articular chondrocytes was investigated. [EF1]Chondrocytes were enzymatically isolated from femoral head cartilage, and were cultured in vitro in monolayer. bFGF-dependent
Shintaro Kanayama et al.
Experimental eye research, 85(6), 772-781 (2007-10-02)
The aim of this study was to compare angiogenesis-induction capabilities of cultured corneal epithelial cells (CCE) and cultured oral mucosal epithelial cells (COE) in vitro, and identify candidate factors that induce corneal neovascularization after transplantation of COE sheets. Rabbit corneal
Michael B Ellman et al.
Gene, 420(1), 82-89 (2008-06-21)
Two members of the fibroblast growth factor (FGF) family, basic FGF (bFGF) and FGF-18, have been implicated in the regulation of articular and intervertebral disc (IVD) cartilage homeostasis. Studies on bFGF from a variety of species have yielded contradictory results
Harris Pratsinis et al.
European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 16(11), 1858-1866 (2007-09-04)
Intervertebral disc (IVD) degeneration is frequently characterized by increased cell proliferation, probably as a tissue regenerative response. Although many growth factors and their receptors have been shown to be expressed normally in the disc, and generally to be over-expressed during
Maria Bodo et al.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 22(6), 621-630 (2002-08-07)
The Crouzon syndrome, which is associated with fibroblast growth factor receptor (FGFR2) mutations, is characterized by premature fusion of cranial sutures. We used an in vitro model of cultured periosteal fibroblasts from normal subjects and from Crouzon patients with FGFR2

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