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Merck
모든 사진(1)

주요 문서

E9902

Sigma-Aldrich

Ephrin-A1/Fc Chimera from mouse

>90% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder

동의어(들):

B61, EFL-1, LERK-1

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About This Item

MDL number:
UNSPSC 코드:
51111800
NACRES:
NA.32

생물학적 소스

mouse

Quality Level

재조합

expressed in NSO cells

분석

>90% (SDS-PAGE)

양식

lyophilized powder

효능

0.16-10 ng/mL

분자량

monomer calculated mol wt 46.8 kDa
50-55 kDa by SDS-PAGE (reducing)

포장

pkg of 200 μg

저장 조건

avoid repeated freeze/thaw cycles

불순물

endotoxin, tested

UniProt 수납 번호

저장 온도

−20°C

유전자 정보

mouse ... Efna1(13636)

생화학적/생리학적 작용

EphA1 (ephrin receptor A1) plays an essential role in development, and is involved in the guidance of axonal and cell migration in nervous system. Disruption of ephrin signaling might be involved in the tumorigenesis of clear cell renal cell carcinoma, and absence of EphA1 has a favorable prognosis in the same. It might also be involved in the tumorigenesis and progression of prostate cancer, and might have potential as a marker for prognosis, as well as a therapeutic target. Studies show that it reduces the risk of Alzheimer′s disease, by hindering pathological changes in brain areas such as, hippocampus, lateral occipitotemporal and inferior temporal gyri. In esophageal squamous cells, it acts as differentiation marker. Its expression is elevated in esophageal squamous cell carcinoma, and this relates to advanced stage and metastasis to lymph node.
Member of ephrin ligand family that binds Eph receptor tyrosine kinases (EphA1, EphA2, EphA3, EphA4, EphA5, EphA6, EphA7 and EphB1). Involved in pattern formation and morphogenesis. Ephrin-A1 can be detected on fetal osteoblasts, odotoblasts, chondrocytes, and squamous epithelium. Ephrin-A1 is expressed during embryonic vasculogenesis and during tumor-induced angiogenesis.

기타 정보

Extracellular domain of mouse ephrin-A1 (amino acids 1-182) fused to the C-terminal 6X histidine-tagged Fc region of human IgG.

물리적 형태

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

분석 메모

The biological activity is measured by its ability to bind recombinant mouse EphA2/Fc in ELISA.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


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문서 라이브러리 방문

Hui-Fu Wang et al.
Journal of Alzheimer's disease : JAD, 44(1), 115-123 (2014-09-04)
Ephrin type-A receptor 1 (EPHA1) (11771145) was documented to be one of the most strongly associated locus with Alzheimer's disease (AD) in a recent meta-analysis of five genome wide association studies. However, its contribution to the pathogenesis of AD remains
Augustin DuSablon et al.
PloS one, 12(12), e0189307-e0189307 (2017-12-14)
EphrinA1, a membrane-bound receptor tyrosine kinase ligand expressed in healthy cardiomyocytes, is lost in injured cells following myocardial infarction. Previously, we have reported that a single intramyocardial injection of chimeric ephrinA1-Fc at the time of ischemia reduced injury in the
Libo Peng et al.
International journal of clinical and experimental pathology, 6(9), 1854-1860 (2013-09-17)
The erythropoietin-producing hepatocellular (Eph) family of receptor tyrosine kinases regulates a multitude of physiological and pathological processes. EphA1 is the first member of Eph superfamily and is involved in carcinogenesis. The aim of this study was to investigate the expression
Matthieu Chavent et al.
Biochemistry, 53(42), 6641-6652 (2014-10-07)
EphA1 is a receptor tyrosine kinase (RTK) that plays a key role in developmental processes, including guidance of the migration of axons and cells in the nervous system. EphA1, in common with other RTKs, contains an N-terminal extracellular domain, a
Jiandong Wang et al.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 121(1), 30-37 (2012-10-04)
Eph receptors play important roles in the development of cancer. The present study aimed to investigate the expression of EphA1 and its clinicopathologic significance in esophageal squamous cell carcinoma (ESCC). The expression levels of the EphA1 transcript and protein were

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