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Merck
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Key Documents

Z4250

Sigma-Aldrich

Zymosan A from Saccharomyces cerevisiae

for inducing inflamatory response

동의어(들):

Yeast Cell Wall

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About This Item

CAS Number:
MDL number:
UNSPSC 코드:
12352202
NACRES:
NA.61

생물학적 소스

Saccharomyces cerevisiae

Quality Level

형태

powder with small lumps

기술

flow cytometry: suitable
tissue culture: suitable

색상

off-white to light brown

저장 온도

2-8°C

유사한 제품을 찾으십니까? 방문 제품 비교 안내

애플리케이션

  • in flow cytometry
  • to study its effect on head kidney leukocytes from rainbow trout (Oncorhynchus mykiss)

Zymosan A from Saccharomyces cerevisiae has been used:
  • as a positive control to determine the activation of complement cascade
  • for respiratory burst (RB) assay
  • to assess its effects on performance, immunity, heat shock protein and apoptosis related gene expressions of dairy cows under heat stress (HS)
  • a stimulating agent in Krebs-Ringer phosphate (KRP) medium
  • to induce thermal hyperalgesia in mice

생화학적/생리학적 작용

Zymosan is prepared from yeast cell wall and consists of protein-carbohydrate complexes. It is used to induce experimental sterile inflammation. In macrophages, zymosan-induced responses include the induction of proinflammatory cytokines, arachidonate mobilization, protein phosphorylation, and inositol phosphate formation. Zymosan A also raises cyclin D2 levels suggesting a role for the latter in macrophage activation besides proliferation. It potentiates acute liver damage after galactosamine injection suggesting that certain types of nonparenchymal cells other than Kupffer cells are involved in zymosan action. Zymosan A, a 13 beta glucan contributes to the development of organic dust-induced respiratory disease.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)


시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

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문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Protective effects of zymosan on heat stress-induced immunosuppression and apoptosis in dairy cows and peripheral blood mononuclear cells
Sun Y, et al.
Cell Stress & Chaperones, 23(5), 1069-1078 (2018)
The G2A receptor controls polarization of macrophage by determining their localization within the inflamed tissue
Kern K, et al.
Frontiers in Immunology, 9, 2261-2261 (2018)
Impact of copper nanoparticles on porcine neutrophils: ultrasensitive characterization factor combining chemiluminescence information and USEtox assessment model
Pu Y, et al.
Materials Today Communications, 11, 68-75 (2017)
Self-mineralizing Ca-enriched Methacrylated Gellan Gum Beads for Bone Tissue Engineering
VieiraS, et al.
Acta Biomaterialia (2019)
Maria M M Kaisar et al.
PLoS biology, 16(4), e2005504-e2005504 (2018-04-19)
The molecular mechanisms through which dendritic cells (DCs) prime T helper 2 (Th2) responses, including those elicited by parasitic helminths, remain incompletely understood. Here, we report that soluble egg antigen (SEA) from Schistosoma mansoni, which is well known to drive

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