추천 제품
생물학적 소스
rabbit
Quality Level
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
형태
buffered aqueous solution
분자량
antigen ~125 kDa
종 반응성
human
포장
antibody small pack of 25 μL
농도
~1.0 mg/mL
기술
western blot: 2-4 μg/mL using K562 cell lysates
UniProt 수납 번호
배송 상태
dry ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... XPO1(7514)
mouse ... Xpo1(103573)
rat ... Xpo1(85252)
일반 설명
Exportin 1/Crm1 (also known as XPO1, Exp1, chromosome region maintenance 1 protein homolog) is mapped to human chromosome 2p15.
애플리케이션
Anti-Exportin 1/Crm1 (C-terminal) antibody produced in rabbit has been used in immunoblotting.
생화학적/생리학적 작용
Exportin 1/Crm1 has been implicated in various steps during mitosis.
Exportin-1 is a protein encoded by the XPO1 gene in humans. It is a novel cell-cycle regulated gene that is essential for the nuclear export signal-dependent nuclear export of proteins. XPO1 is highly expressed in mantle cell lymphoma (MCL) cells. It acts as selective inhibitor of nuclear export (SINE) compounds that induce apoptosis in MCL cells. XPO1 is expressed in subpopulation of Gastric cancer (GC) with aggressive behavior and can serve as a prognosis marker for poor outcome. It has helical hairpin HEAT repeats and a C-terminal helical extension (C-extension). The C-extension helps in regulating CRM1′s cargo-binding affinity by modulating the conformation and flexibility of its HEAT repeats.
물리적 형태
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 1
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
CRM1-mediated nuclear export: to the pore and beyond
Hutten S, et al.
Trends in Cell Biology, 193-201 (2007)
Toshie Sakuma et al.
Journal of virology, 88(8), 4069-4082 (2014-01-31)
Intron-containing mRNAs are subject to restricted nuclear export in higher eukaryotes. Retroviral replication requires the nucleocytoplasmic transport of both spliced and unspliced RNA transcripts, and RNA export mechanisms of gammaretroviruses are poorly characterized. Here, we report the involvement of the
J Schmidt et al.
Leukemia, 27(12), 2357-2365 (2013-06-12)
RNA interference screening identified XPO1 (exportin 1) among the 55 most vulnerable targets in multiple myeloma (MM). XPO1 encodes CRM1, a nuclear export protein. XPO1 expression increases with MM disease progression. Patients with MM have a higher expression of XPO1
Fang Zhou et al.
Medical oncology (Northwood, London, England), 30(4), 726-726 (2013-09-13)
Gastric cancer (GC) is a highly aggressive malignant tumor. Its high mortality rate prompts the urgent need for novel therapeutic agents. The aim of this study is to detect the expression of CRM1 in GC, which has not been reported
Effects of exportin 1 on nuclear transport and meiotic resumption in porcine full-grown and growing oocytes
Onuma A, et al.
Biology of Reproduction, 98(4), 501-509 (2017)
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