E4642

(±)-Epinephrine hydrochloride

≥98% (TLC), powder, adrenergic receptor agonist

• 동의어(들): (±)-Adrenalin, 4-(1-Hydroxy-2-[methylamino]ethyl)-1,2-benzenediol hydrochloride
• 실험식(Hill 표기법): C₉H₁₃NO₃ · HCl
• CAS Number: 329-63-5
• Molecular Weight: 219.67
• EC Number: 206-346-0
• MDL number: MFCD00050562
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24278422
• NACRES: NA.77

속성

• product name: (±)-Epinephrine hydrochloride,
• Quality Level: 200
• solubility: H₂O: 50 mg/mL
• 저장 온도: 2-8°C
• SMILES string: OC(CNC)C1=CC=C(O)C(O)=C1.Cl
• InChI: 1S/C9H13NO3.ClH/c1-10-5-9(13)6-2-3-7(11)8(12)4-6;/h2-4,9-13H,5H2,1H3;1H
• InChI key: ATADHKWKHYVBTJ-UHFFFAOYSA-N
• 유전자 정보: human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146) , ADRA2A(150) , ADRA2B(151) , ADRA2C(152) , ADRB1(153) , ADRB2(154) , ADRB3(155)

설명

일반 설명

Epinephrine (adrenalin) is synthesized from norepinephrine (noradrenalin) by the action of the enzyme phenylethanolamine N-methyltransferase. Epinephrine comprises 5%-10% of the total catecholamines in the central nervous system. It is a mixed α/β-adrenergic receptor agonist and stimulates these receptors. Their site of synthesis is adrenal medulla and it travels through the vascular systems. Its breakdown occurs in the central nervous system (CNS), liver and kidney.

애플리케이션

(±)-Epinephrine hydrochloride has been used:

• in the induction of renalase expression in Human renal proximal tubular epithelial cells
• in the infusion studies to test its effect on heart rate and eye temperature measurements in bull
• as a medium supplement for the stimulation of endothelial progenitor cells

생화학적/생리학적 작용

Epinephrine improves systemic pressure during cardiopulmonary resuscitation and is used post cardiac arrest. The levels of epinephrine increases during trauma, sepsis and hypoglycemia resulting in increased cardiac rate and contractility. It is used in the treatment of acute anaphylaxis. Use of epinephrine hydrochloride enables dilation of pupil during intraocular lens (IOL) implantation surgery.

Adrenergic receptor agonist.

안전성 정보

• 픽토그램: GHS06
• 신호어: Danger
• 유해 및 위험 성명서: H301 + H311,H315,H319,H335
• 예방조치 성명서: P261 - P264 - P280 - P301 + P310 - P302 + P352 + P312 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 표적 기관: Respiratory system
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges