추천 제품
product name
β-Endothelial Cell Growth Factor human, β-ECGF, recombinant, expressed in E. coli, suitable for cell culture
생물학적 소스
human
재조합
expressed in E. coli
분석
≥97% (SDS-PAGE)
형태
lyophilized powder
효능
0.03-0.3 ng/mL ED50/EC50
품질
endotoxin tested
분자량
predicted mol wt ~17 kDa
포장
pkg of 25 μg
저장 조건
avoid repeated freeze/thaw cycles (Do not store in a frost-free freezer.)
기술
cell culture | mammalian: suitable
불순물
≤1.0 EU/μg protein Endotoxin level (LAL test)
UniProt 수납 번호
저장 온도
−20°C
유전자 정보
human ... VEGFB(7423)
일반 설명
The β-endothelial cell growth factor (b-ECGF) gene encodes an angiogenic factor, and is mapped to human chromosome 11q13.1. Recombinant, human b-endothelial cell growth factor (b-ECGF) is a 14 amino acid N-terminal extension of acidic fibroblast growth factor. It is expressed in Escherichia coli. The 154 amino acid recombinant protein, generated after removal of the initiation methionine, has a predicted molecular mass of about 17 kDa.
애플리케이션
β-Endothelial Cell Growth Factor human has been used:
- in cell death assay
- in endothelial cell culture
- in human umbilical vascular endothelial cell (HUVEC) culture
생화학적/생리학적 작용
β-Endothelial cell growth factor (β-ECGF) is a potent endothelial cell mitogen and its mitogenic activity is potentiated by heparin. β-ECGF stimulates the growth of quiescent HUVEC cells in culture. β-ECGF is associated with lipid and glucose metabolism. This growth factor induces neovascularization in disease conditions. Upregulation of β-ECGF is observed in diabetic retinopathy, and polycystic ovary syndrome. It is also associated with tumor proliferation and invasion. β-ECGF increases fatty acid transport proteins expression to improve endothelial mediated lipid transpor.
기타 정보
14 amino acid, N-terminal extended form of human FGF-acidic.
물리적 형태
Lyophilized from a 0.2 μm filtered solution in 10 mM MOPS, 50 mM ammonium sulfate, 0.2 mM DTT, and 0.2 mM EDTA, pH 7.2, containing 50 μg bovine serum albumin per 1 μg cytokine.
분석 메모
The proliferative activity is tested in culture by using quiescent NR6R-3T3 fibroblasts.
Storage Class Code
11 - Combustible Solids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
이미 열람한 고객
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Cheng F, et al.
Clinical Endocrinology, 84(3), 386-393 (2016)
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Methods in molecular biology (Clifton, N.J.), 2475, 223-228 (2022-04-23)
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Bioinformatics analyses of the role of vascular endothelial growth factor in patients with non-small cell lung cancer
Wang Y, et al.
PLoS ONE, 10(9), e0139285-e0139285 (2015)
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