D2521

(+)-cis-Diltiazem hydrochloride

≥99% (HPLC)

• 동의어(들): (2S,3S)-(+)-cis-3-Acetoxy-5-(2-dimethylaminoethyl)-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one hydrochloride, CRD-401
• 실험식(Hill 표기법): C₂₂H₂₆N₂O₄S · HCl
• CAS Number: 33286-22-5
• Molecular Weight: 450.98
• Beilstein: 4228706
• EC Number: 251-443-3
• MDL number: MFCD00069252
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24277849
• NACRES: NA.77

속성

• 분석: ≥99% (HPLC)
• 양식: powder
• 주관자: Valeant
• 저장 온도: 2-8°C
• SMILES string: Cl.COc1ccc(cc1)[C@@H]2Sc3ccccc3N(CCN(C)C)C(=O)[C@@H]2OC(C)=O
• InChI: 1S/C22H26N2O4S.ClH/c1-15(25)28-20-21(16-9-11-17(27-4)12-10-16)29-19-8-6-5-7-18(19)24(22(20)26)14-13-23(2)3;/h5-12,20-21H,13-14H2,1-4H3;1H/t20-,21+;/m1./s1
• InChI key: HDRXZJPWHTXQRI-BHDTVMLSSA-N
• 유전자 정보: human ... CACNA1C(775) , CACNA1D(776) , CACNA1F(778) , CACNA1S(779)

설명

일반 설명

Diltiazem hydrochloride is used to treat cardiovascular diseases, such as angina and hypertension. It acts as an inhibitor to cytochrome P450 3A (CYP3A). Diltiazem might be associated with maculopapular rashes, urticaria and pruritus.

애플리케이션

(+)-cis-Diltiazem hydrochloride has been used:

• to study its effects on diffusion and release in monolithic dispersion matrix(26)
• to study its neuroprotective effects in retinitis pigmentosa (RP) models(27)
• as an antagonist against the Cav1.2 L-type calcium channels (LTCCs)(28)

생화학적/생리학적 작용

Blocks slow, or L-type Ca²⁺ channels; regulates Ca²⁺ release from intracellular stores in neutrophils; stimulates 1,4-dihydropyridine binding to Ca²⁺ channels; coronary vasodilator.

특징 및 장점

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Calcium Channels and Cyclic Nucleotide-Gated (CNG) and Hyperpolarization Activated Cyclic Nucleotide-Gated (HCN) Channels pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Valeant. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

기타 정보

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302
• 예방조치 성명서: P264 - P270 - P301 + P312 + P330 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves