D0676

Dobutamine hydrochloride

≥98% (TLC), powder, α1, β1 and β2-adrenoceptor agonist

• 동의어(들): (±)-3,4-Dihydroxy-N-[3-(4-hydroxyphenyl)-1-methylpropyl]-β-phenethylamine hydrochloride
• 실험식(Hill 표기법): C₁₈H₂₃NO₃ · HCl
• CAS Number: 49745-95-1
• Molecular Weight: 337.84
• EC Number: 256-464-1
• MDL number: MFCD00153795
• UNSPSC 코드: 12352116
• PubChem Substance ID: 24277772
• NACRES: NA.77

속성

• product name: Dobutamine hydrochloride, ≥98%
• Quality Level: 200
• 분석: ≥98%
• 형태: powder
• 주관자: Eli Lilly
• 저장 온도: 2-8°C
• SMILES string: Cl[H].CC(CCc1ccc(O)cc1)NCCc2ccc(O)c(O)c2
• InChI: 1S/C18H23NO3.ClH/c1-13(2-3-14-4-7-16(20)8-5-14)19-11-10-15-6-9-17(21)18(22)12-15;/h4-9,12-13,19-22H,2-3,10-11H2,1H3;1H
• InChI key: BQKADKWNRWCIJL-UHFFFAOYSA-N
• 유전자 정보: human ... ADRB1(153) , ADRB2(154)

설명

애플리케이션

Dobutamine hydrochloride has been used:

• to treat mouse embryonic fibroblasts for cell death analysis
• to inhibit TAZ (transcriptional coactivator with PDZ-binding motif)/YAP (Yes-associated protein) of Hippo pathway and study its effect on tumor cell proliferation
• as β1-AR partial agonist to determine its effects on budding of endophilin-mRFP-positive structures by live-cell imaging

생화학적/생리학적 작용

Dobutamine is a synthetic catecholamine that stimulate the β1 -adrenoceptor receptor. It exhibits inotropic outcome on the myocardium. Dobutamine elevates contractility and is known to be useful in the condition of low blood pressure.

특징 및 장점

This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

안전성 정보

• 픽토그램: GHS08,GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302 + H312 + H332,H361fd
• 예방조치 성명서: P202 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Repr. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• 개인 보호 장비: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges