추천 제품
재조합
expressed in E. coli BL21
Quality Level
양식
solution
특이 활성도
50-100 units/μg protein
포장
vial of 300 units
배송 상태
dry ice
저장 온도
−70°C
애플리케이션
Human cyclin-dependent kinase 5 has been used in a study to determine its 3′ untranslated region subunit 1 contains regulatory elements that affect transcript stability.
생화학적/생리학적 작용
CDK5 is highly expressed in the nervous system where it phosphorylates a multitude of substrates. CDK5 plays an important role in many processes such as: apoptosis, phototransduction, dopamine and glutamate signalling, neurite outgrowth, neurone migration, induction of acetylcholine receptors, golgi membrane traffic and insulin exocytosis. It has also been implicated in the pathogenesis of amyotrophic lateral sclerosis . It is activated by p35 and p39, and their proteolytic cleavage products, p25 and p29.
단위 정의
One unit will phosphorylate 1.0 picomole of the peptide substrate histone H19-18 per minute at 30 °C at pH 7.4.
물리적 형태
Supplied as a solution in PBS pH 7.4, 1 mM EDTA, 1mM DTT and 1 mg/ml BSA
Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
가장 최신 버전 중 하나를 선택하세요:
Kwok-On Lai et al.
The Journal of biological chemistry, 290(23), 14637-14646 (2015-04-24)
The maturation and maintenance of dendritic spines depends on neuronal activity and protein synthesis. One potential mechanism involves mammalian target of rapamycin, which promotes protein synthesis through phosphorylation of eIF4E-binding protein and p70 ribosomal S6 kinase 1 (S6K). Upon extracellular
Pharmacological inhibitors of cyclin-dependent kinases
Knockaert M, et al.
Trends in Pharmacological Sciences, 23(9), 417-425 (200)
Silvia Moncini et al.
BMC molecular biology, 8, 111-111 (2007-12-07)
CDK5R1 plays a central role in neuronal migration and differentiation during central nervous system development. CDK5R1 has been implicated in neurodegenerative disorders and proposed as a candidate gene for mental retardation. The remarkable size of CDK5R1 3'-untranslated region (3'-UTR) suggests
Shu Zhang et al.
PloS one, 10(7), e0131833-e0131833 (2015-07-07)
Cyclin-dependent kinase 5 (CDK5) is a cytoplasmic serine/ threonine kinase. Knockdown of CDK5 enhances paclitaxel sensitivity in human ovarian cancer cells. This study explores the mechanisms by which CDK5 regulates paclitaxel sensitivity in human ovarian cancers. Multiple ovarian cancer cell
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