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Merck
모든 사진(1)

주요 문서

C7745

Sigma-Aldrich

CDK7/Cyclin H1/MNAT1, active, His tagged human

PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

동의어(들):

CAK, CCNH, CDKN7, MAT1, P39mo15, RNF66, STK1, p34, p37

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About This Item

UNSPSC 코드:
12352200
NACRES:
NA.32

재조합

expressed in baculovirus infected Sf9 cells

Quality Level

제품 라인

PRECISIO® Kinase

분석

≥70% (SDS-PAGE)

형태

buffered aqueous glycerol solution

특이 활성도

17-22 nmol/min·mg

분자량

CDK7 subunit ~40 kDa
MNAT1 subunit ~37 kDa
cyclin D1 ~39 kDa

UniProt 수납 번호

배송 상태

dry ice

저장 온도

−70°C

유전자 정보

생화학적/생리학적 작용

CDK7 gene is a member of the cyclin-dependent protein kinase family that is important regulators of cell cycle progression. CDK7 forms a trimeric complex with cyclin H and MAT1, which functions as a CDK-activating kinase (CAK). CDK7 is an essential component of the transcription factor TFIIH that is involved in transcription initiation and DNA repair. CDK7 is thought to serve as a direct link between the regulation of transcription and the cell cycle.

물리적 형태

Supplied in 50mM NaPhosphate pH 7.0, 300 mM NaCl, 150 mM imidazole, 0.1mM PMSF, 0.2 mM DTT, 25% glycerol.

법적 정보

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

픽토그램

Health hazardExclamation mark

신호어

Danger

유해 및 위험 성명서

Hazard Classifications

Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Faceshields, Gloves, multi-purpose combination respirator cartridge (US)


시험 성적서(COA)

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문서 라이브러리 방문

Stéphane Larochelle et al.
Molecular cell, 25(6), 839-850 (2007-03-28)
Cell division is controlled by cyclin-dependent kinases (CDKs). In metazoans, S phase onset coincides with activation of Cdk2, whereas Cdk1 triggers mitosis. Both Cdk1 and -2 require cyclin binding and T loop phosphorylation for full activity. The only known CDK-activating
R P Fisher et al.
Cell, 78(4), 713-724 (1994-08-26)
Phosphorylation by the CDK-activating kinase (CAK) is a required step in the activation of cyclin-dependent kinases. We have purified CAK from mammalian cells; the enzyme comprises two major polypeptides of 42 and 37 kDa. Protein sequencing indicates that the 42

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