추천 제품
분석
~98% (HPLC)
Quality Level
형태
solid
색상
off-white
solubility
DMSO: >10 mg/mL
H2O: insoluble
주관자
Roche
저장 온도
2-8°C
SMILES string
CCC(CC)(CC(=O)Nc1cccc(\C=C\c2nc(cs2)C3CCC3)c1)C(O)=O
InChI
1S/C23H28N2O3S/c1-3-23(4-2,22(27)28)14-20(26)24-18-10-5-7-16(13-18)11-12-21-25-19(15-29-21)17-8-6-9-17/h5,7,10-13,15,17H,3-4,6,8-9,14H2,1-2H3,(H,24,26)(H,27,28)/b12-11+
InChI key
BZMKNPGKXJAIDV-VAWYXSNFSA-N
유전자 정보
human ... CYSLTR1(10800)
생화학적/생리학적 작용
Specific CysLT1 leukotriene receptor antagonist.
특징 및 장점
This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Synergism exhibited by LTD4 and PAF receptor antagonists in decreasing antigen-induced airway microvascular leakage.
M A Wasserman et al.
Advances in prostaglandin, thromboxane, and leukotriene research, 23, 271-273 (1995-01-01)
Studies of the combination of Ro 24-5913, a peptidoleukotriene antagonist, and Ro 24-4736, a PAF antagonist, in guinea pig and rat models of lung inflammation.
A F Welton et al.
Annals of the New York Academy of Sciences, 744, 274-288 (1994-11-15)
Degradation profile and reversed-phase LC method development of the antiinflammatory drug, Ro 24-5913.
N D Aggarwal et al.
Journal of pharmaceutical and biomedical analysis, 11(10), 1037-1043 (1993-10-01)
M O'Donnell et al.
The Journal of pharmacology and experimental therapeutics, 259(2), 751-758 (1991-11-01)
Ro 24-5913, (E)-4-[3-[2-(4-cyclobutyl-2- thiazolyl)ethenyl]phenylamino]-2,2-diethyl-4-oxobutanoic acid, has been identified as a chemically unique, potent and selective LTD4 antagonist. In vitro, Ro 24-5913 competes with [3H]LTD4 for its binding site on guinea pig lung membranes with an IC50 of 6.4 +/- 2.2
I Durán Merás et al.
Journal of pharmaceutical and biomedical analysis, 43(3), 1025-1032 (2006-11-23)
A fluorimetric study on the spectral characteristics of two antileukotrienes, cinalukast and montelukast, has been performed. Ionization constants of both of them have been photometrically calculated. Cinalukast pK(a) in ethanol:water 50:50 (v/v) medium resulted to be 2.2+/-0.1. Because the spectral
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