C2743

Cytochalasin B from Drechslera dematioidea

Ready Made Solution, 10 mg/mL in DMSO

• 동의어(들): Phomin
• 실험식(Hill 표기법): C₂₉H₃₇NO₅
• CAS Number: 14930-96-2
• Molecular Weight: 479.61
• Beilstein: 1096207
• MDL number: MFCD00077704
• UNSPSC 코드: 51102829
• PubChem Substance ID: 329774749
• NACRES: NA.85

속성

• Quality Level: 200
• 형태: solution
• 농도: 10 mg/mL in DMSO
• 항생제 활성 스펙트럼: fungi
• 동작 모드: cell membrane | interferes
• 저장 온도: −20°C
• SMILES string: C[C@@H]1CCC[C@@H](O)\C=C\C(=O)O[C@]23[C@@H](\C=C\C1)[C@H](O)C(=C)[C@@H](C)[C@H]2[C@H](Cc4ccccc4)NC3=O
• InChI: 1S/C29H37NO5/c1-18-9-7-13-22(31)15-16-25(32)35-29-23(14-8-10-18)27(33)20(3)19(2)26(29)24(30-28(29)34)17-21-11-5-4-6-12-21/h4-6,8,11-12,14-16,18-19,22-24,26-27,31,33H,3,7,9-10,13,17H2,1-2H3,(H,30,34)/b14-8+,16-15+/t18-,19-,22-,23+,24+,26+,27-,29-/m1/s1
• InChI key: GBOGMAARMMDZGR-TYHYBEHESA-N

설명

애플리케이션

Cytochalasin B from Drechslera dematioidea has been used:

• to block cytokinesis, to obtain binucleated cells
• as a specific glucose transporter inhibitor
• to inhibit glucose transport by class I and III GLUTs to determine the 50% inhibitory concentration (IC50) in HCMV-infected and mock-infected cells

Cytochalasin B is used to inhibit sugar transport in fibroblasts , decrease cytoskeletal actin and myosin in rabbit neutrophils , and to stimulate B lymphocytes .

생화학적/생리학적 작용

Cell permeable fungal toxin that disrupts contractile microfilaments by inhibiting actin polymerization. This, in turn, induces DNA fragmentation, inhibits cell division, and disrupts many cell processes. Inhibits glucose transport.

Cytochalasin B can prevent cytoplasmic division without affecting nuclear division.

One of a group of fungal metabolites that interfere with a wide variety of cellular movements. Useful tool for characterizing some of the polymerization properties of actin, and in studies on cytokinesis. Probe for the two hexose-transport systems in rat L6 myoblasts.

기타 정보

Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.

안전성 정보

• 픽토그램: GHS06
• 신호어: Danger
• 유해 및 위험 성명서: H302,H330
• 예방조치 성명서: P260 - P264 - P270 - P271 - P301 + P312 - P304 + P340 + P310
• Hazard Classifications: Acute Tox. 2 Inhalation - Acute Tox. 4 Oral
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 2
• Flash Point (°F): 185.0 °F - closed cup - Solvent
• Flash Point (°C): 85 °C - closed cup - Solvent
• 개인 보호 장비: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter