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Merck
모든 사진(1)

주요 문서

C0399

Sigma-Aldrich

Cromolyn sodium salt

≥95%

동의어(들):

Cromoglycate, Cromoglycic acid

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About This Item

Linear Formula:
C23H14O11Na2
CAS Number:
Molecular Weight:
512.33
EC Number:
MDL number:
UNSPSC 코드:
12352200
PubChem Substance ID:
NACRES:
NA.77

Quality Level

분석

≥95%

양식

powder

주관자

Sanofi Aventis

SMILES string

[Na].OC(COc1cccc2OC(=CC(=O)c12)C(O)=O)COc3cccc4OC(=CC(=O)c34)C(O)=O

InChI

1S/C23H16O11.Na.H/c24-11(9-31-14-3-1-5-16-20(14)12(25)7-18(33-16)22(27)28)10-32-15-4-2-6-17-21(15)13(26)8-19(34-17)23(29)30;;/h1-8,11,24H,9-10H2,(H,27,28)(H,29,30);;

InChI key

UXMUBZWVLQEMRB-UHFFFAOYSA-N

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일반 설명

Cromolyn sodium is a mast stabilizer, which is used to treat allergies. It is a bischromone and functions as a non-steroidal anti-inflammatory drug. It inhibits the release of histamines from mast cells.

애플리케이션

Cromolyn sodium salt has been used to block mast cell activation and to inhibit histamine secretion from rodent peritoneal mast cells. It has also been used to stabilize mast cells.

생화학적/생리학적 작용

Cromolyn blocks the release of histamine and other pro-inflammatory mediators from mast cells.

특징 및 장점

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

픽토그램

Exclamation mark

신호어

Warning

유해 및 위험 성명서

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

표적 기관

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

dust mask type N95 (US), Eyeshields, Gloves


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시험 성적서(COA)

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이 제품을 이미 가지고 계십니까?

문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Aluminum Ingestion Promotes Colorectal Hypersensitivity in Rodents
Esquerre N, et al.
Cellular and molecular gastroenterology and hepatology, 7(1), 185-196 (2019)
Rhinitis, An Issue of Immunology and Allergy Clinics - E-Book (2011)
Mechanistic understanding of oral drug absorption enhancement of cromolyn sodium by an amino acid derivative
Alani AWG and Robinson JR
Pharmaceutical Research, 25(1), 48-54 (2008)
Reginald Gorczynski et al.
Transplantation, 97(1), 39-46 (2013-10-22)
Rejection is associated with early degranulation (≥80%) of graft-infiltrating CD200R1 receptor-positive mast cells (MCs). Survival is increased, and MC degranulation is decreased, in CD200 mice but not in CD200R1KO mice. CD200 engagement of CD200R2 (not present on MCs) alters dendritic
Zhi Liu et al.
Journal of autoimmunity, 31(4), 331-338 (2008-10-17)
Bullous pemphigoid (BP) is a cutaneous autoimmune inflammatory disease associated with subepidermal blistering and autoantibodies against BP180, a transmembrane collagen and major component of the hemidesmosome. Numerous inflammatory cells infiltrate the upper dermis in BP. IgG autoantibodies in BP fix

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