추천 제품
양식
powder
Quality Level
색상
white
solubility
chloroform: soluble (but decomposes within 24 hrs)
methanol: stable (for up to two weeks at -20°C.)
εmax
13,500 at 207.4 nm in methanol
저장 온도
2-8°C
SMILES string
OC(C(=O)OC1CN2CCC1CC2)(c3ccccc3)c4ccccc4
InChI
1S/C21H23NO3/c23-20(25-19-15-22-13-11-16(19)12-14-22)21(24,17-7-3-1-4-8-17)18-9-5-2-6-10-18/h1-10,16,19,24H,11-15H2
InChI key
HGMITUYOCPPQLE-UHFFFAOYSA-N
생화학적/생리학적 작용
Nonselective muscarinic acetylcholine receptor antagonist.
특징 및 장점
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
신호어
Danger
유해 및 위험 성명서
예방조치 성명서
Hazard Classifications
Acute Tox. 2 Oral
Storage Class Code
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
가장 최신 버전 중 하나를 선택하세요:
Monica Salani et al.
Journal of neurochemistry, 108(3), 821-834 (2009-02-04)
Neurotransmitters are considered part of the signaling system active in nervous system development and we have previously reported that acetylcholine (ACh) is capable of enhancing neuronal differentiation in cultures of sensory neurons and N18TG2 neuroblastoma cells. To study the mechanism
José N Nobrega et al.
Journal of pharmacological and toxicological methods, 86, 28-33 (2017-03-10)
Assessments of total anticholinergic activity (SAA) in serum are of considerable interest for its potential involvement in cognitive impairment associated with polydrug states in the elderly and other populations. Such estimations have been based on the displacement of radioligand binding
Koji Hori et al.
Neuropsychobiology, 63(3), 147-153 (2011-01-14)
Alzheimer's disease (AD) is well known as a disease characterized by degeneration of cholinergic neuronal activity in the brain. It follows that patients with AD would be sensitive to an 'anticholinergic burden', and also that medicine with anticholinergic properties would
Kylie J Mansfield et al.
The Journal of pharmacology and experimental therapeutics, 328(3), 893-899 (2008-11-26)
Recent studies have described muscarinic receptors on the mucosa and the detrusor of the human urinary bladder. Muscarinic receptor antagonists are effective in the treatment of overactive bladder (OAB), but their site(s) of action and actual therapeutic target are unclear.
Barbara C van Munster et al.
Journal of psychiatric research, 46(10), 1339-1345 (2012-08-01)
Delirium, a frequently occurring, devastating disease, is often underdiagnosed, especially in dementia. Serum anticholinergic activity (SAA) was proposed as a disease marker as it may reflect delirium's important pathogenetic mechanism, cholinergic deficiency. We assessed the association of serum anticholinergic activity
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