B133

(S)-(−)-Bay K8644

≥98% (HPLC), solid

• 동의어(들): S-(−)-1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid methyl ester
• 실험식(Hill 표기법): C₁₆H₁₅F₃N₂O₄
• CAS Number: 98625-26-4
• Molecular Weight: 356.30
• MDL number: MFCD00153769
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24891582
• NACRES: NA.77

속성

• 분석: ≥98% (HPLC)
• 양식: solid
• 색상: yellow
• solubility: H₂O: slightly soluble; ethanol: soluble (Organic solutions are stable for at least 20 days at RT.)
• 저장 온도: 2-8°C
• SMILES string: COC(=O)C1=C(C)NC(C)=C([C@H]1c2ccccc2C(F)(F)F)[N+]([O-])=O
• InChI: 1S/C16H15F3N2O4/c1-8-12(15(22)25-3)13(14(21(23)24)9(2)20-8)10-6-4-5-7-11(10)16(17,18)19/h4-7,13,20H,1-3H3/t13-/m0/s1
• InChI key: ZFLWDHHVRRZMEI-ZDUSSCGKSA-N
• 유전자 정보: human ... ADORA3(140) ; rat ... Adora1(29290) , Adora2a(25369)

설명

일반 설명

(S)-(-)-Bay K8644, a dihydropyridine compound is a Ca²⁺ channel activator. It is an enantiomer of Bay K 8644.

애플리케이션

(S)-(-)-Bay K8644 has been used as a L-type calcium channel (LTCC) agonist in the suprachiasmatic nucleus (SCN) slices. It has also been used as a LTCC agonist to induce arrhythmia in rats.

생화학적/생리학적 작용

(S)-(-)-Bay K8644 enhances Ca²⁺ current, whereas the (+)-Bay K 8644 is a weak Ca²⁺ channel antagonist. Bay K 8644 is lipophilic and it effectively scavenges superoxide anions.

특징 및 장점

This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

법적 정보

Manufactured and sold with the permission of Bayer AG.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H315,H319
• 예방조치 성명서: P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves