B1059

Bcl-w (Minus C-Terminus) human

>95% (SDS-PAGE), recombinant, expressed in E. coli, buffered aqueous glycerol solution

• MDL number: MFCD03846039
• UNSPSC 코드: 12352202
• NACRES: NA.32

속성

• 재조합: expressed in E. coli
• Quality Level: 200
• 분석: >95% (SDS-PAGE)
• 형태: buffered aqueous glycerol solution
• 분자량: 18 kDa by SDS-PAGE
• UniProt 수납 번호: Q92843
• 배송 상태: wet ice
• 저장 온도: −20°C
• 유전자 정보: human ... BCL2L2(599)

설명

일반 설명

This recombinant Bcl-w lacks the mitochondrial targeting sequence but maintains the ability to neutralize pro-apoptotic Bcl-2 family members.

생화학적/생리학적 작용

Like Bcl-2 and Bcl-x, the Bcl-w protein promotes cell survival, in contrast to other close homologues, Bax and Bak, which facilitate cell death. Bcl-w is an anti-apoptotic member of the Bcl-2 family that prevents release of cytochrome c from the mitochondrial intermembrane space into the cytosol. It is required for normal sperm maturation. Natural Bcl-w contains a C-terminal mitochondrial targeting sequence.

물리적 형태

Supplied as a 0.2 μm filtered solution in 25 mM HEPES, pH 7.5, 0.1 M KCl, and 10% glycerol.

분석 메모

Measured by its ability to inhibit caspase-8-cleaved human BID-mediated release of cytochrome c from isolated mouse liver mitochondria using ELISA.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)