A9101

Acetylcholine chloride

≥99% (TLC), powder or crystals

• 동의어(들): ACh
• Linear Formula: (CH₃)₃N⁺CH₂CH₂OCOCH₃Cl^-
• CAS Number: 60-31-1
• Molecular Weight: 181.66
• Beilstein: 3571875
• EC Number: 200-468-8
• MDL number: MFCD00011698
• UNSPSC 코드: 12352204
• PubChem Substance ID: 57653883
• NACRES: NA.32

속성

• 제품명: Acetylcholine chloride, pkg of 150 mg (per vial)
• 분석: ≥99% (TLC)
• Quality Level: 100
• 양식: powder or crystals
• 포장: pkg of 150 mg (per vial)
• mp: 146-150 °C (lit.)
• solubility: H₂O: soluble
• 저장 온도: room temp
• SMILES string: [Cl-].CC(=O)OCC[N+](C)(C)C
• InChI: 1S/C7H16NO2.ClH/c1-7(9)10-6-5-8(2,3)4;/h5-6H2,1-4H3;1H/q+1;/p-1
• InChI key: JUGOREOARAHOCO-UHFFFAOYSA-M
• 유전자 정보: human ... CHRM3(1131)

설명

일반 설명

Acetylcholine is an important neurotransmitter that plays a critical role in multiple neurological systems. Crucial for neurobiology studies, acetylcholine aids researchers in understanding synaptic transmission. In other forms of research, acetylcholine has an effect and influence on tumor neurobiology for cancer R&D, as well as a variety of other cognitive processes.

애플리케이션

For use as a substrate to determine acetylcholinesterase activity. Acetylcholine chloride has been used:

• for standard curve preparation in hestrin assay
• in Protein expression, radioactive ligand binding assay and electrophysiological studies of Lymnaea stagnalis acetylcholine binding protein (Ls-AChBPs)
• as a supplement in extracellular solutions for treating the voltage clamped cells in electrophysiology studies

생화학적/생리학적 작용

Acetyl choline (ACh) is an essential neurotransmitter in both central and peripheral nervous system. ACh binds to nicotinic acetylcholine receptors (nAChRs) and causes fast excitatory neurotransmission.

Acetylcholine chloride, injected at 20 mg/kg body weight, reduces mortality and plasma proinflammatory cytokines in mice with experimentally-induced sepsis . The cholinergic anti-inflammatory mechanism is probably mediated by interaction of acetylcholine with α7n cholinoreceptor on monocytes, macrophages, and neutrophils, which decreases the levels of proinflammatory cytokines such as TNF-α, IL-1β, and IL-6.

Endogenous neurotransmitter at cholinergic synapses; amplifies action potential of the sarcolemma thereby inducing muscle contractions.

재구성

Reconstituted solution is stable for 2 weeks when stored at 2-8 °C

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves