PHR1546

Acetylcholine chloride

Pharmaceutical Secondary Standard; Certified Reference Material

• 동의어(들): Acetylcholine chloride, ACh
• Linear Formula: (CH₃)₃N⁺CH₂CH₂OCOCH₃Cl^-
• CAS Number: 60-31-1
• Molecular Weight: 181.66
• Beilstein: 3571875
• EC Number: 200-468-8
• MDL number: MFCD00011698
• UNSPSC 코드: 41116107
• PubChem Substance ID: 329823455
• NACRES: NA.24

속성

• Grade: certified reference material; pharmaceutical secondary standard
• Quality Level: 300
• Agency: traceable to Ph. Eur. Y0000002; traceable to USP 1008501
• API family: acetylcholine
• CofA: current certificate can be downloaded
• 포장: pkg of 500 mg
• 기술: HPLC: suitable; gas chromatography (GC): suitable
• mp: 146-150 °C (lit.)
• 응용 분야: pharmaceutical (small molecule)
• 형식: neat
• 저장 온도: 2-8°C
• SMILES string: [Cl-].CC(=O)OCC[N+](C)(C)C
• InChI: 1S/C7H16NO2.ClH/c1-7(9)10-6-5-8(2,3)4;/h5-6H2,1-4H3;1H/q+1;/p-1
• InChI key: JUGOREOARAHOCO-UHFFFAOYSA-M
• 유전자 정보: human ... CHRM3(1131)

설명

일반 설명

Acetylcholine chloride is a stable cholinergic agonist with muscarinic and nicotinic actions.

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

애플리케이션

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Acetylcholine chloride may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical preparation using high-performance liquid chromatography/electrospray ionization mass spectrometry.

생화학적/생리학적 작용

Acetylcholine chloride, injected at 20 mg/kg body weight, reduces mortality and plasma proinflammatory cytokines in mice with experimentally-induced sepsis . The cholinergic anti-inflammatory mechanism is probably mediated by interaction of acetylcholine with α7n cholinoreceptor on monocytes, macrophages, and neutrophils, which decreases the levels of proinflammatory cytokines such as TNF-α, IL-1β, and IL-6.

분석 메모

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

기타 정보

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

각주

To see an example of a Certificate of Analysis for this material enter LRAB0912 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

추천 제품

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable