A8626

Adenine

≥99%

• 동의어(들): 6-Aminopurine, Vitamin B₄
• 실험식(Hill 표기법): C₅H₅N₅
• CAS Number: 73-24-5
• Molecular Weight: 135.13
• Beilstein: 5777
• EC Number: 200-796-1
• MDL number: MFCD00041790
• UNSPSC 코드: 41106305
• PubChem Substance ID: 24891349
• NACRES: NA.51

속성

• 생물학적 소스: synthetic
• Quality Level: 200
• 분석: ≥99%
• 형태: powder
• 기술: UV/Vis spectroscopy: suitable
• 색상: white to off-white
• mp: >360 °C (lit.)
• solubility: 0.5 M HCl: soluble 20 mg/mL, Grade III, colorless to faint yellow or tan
• 저장 온도: room temp
• SMILES string: Nc1ncnc2[nH]cnc12
• InChI: 1S/C5H5N5/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H3,6,7,8,9,10)
• InChI key: GFFGJBXGBJISGV-UHFFFAOYSA-N
• 유전자 정보: human ... AKT1(207) , GSK3B(2932) , LCK(3932) , MAP3K1(4214) , MAPK14(1432) , MAPK8(5599) , MAPK9(5601) , MAPKAPK2(9261) , PRKACA(5566) , PRKCA(5578) , RAF1(5894) , ROCK2(9475) ; mouse ... Mapk1(26413) ; rat ... Camk2a(25400) , Mapk10(25272)

설명

일반 설명

Adenine is a purine nucleobase. It is part of DNA, and RNA. Adenine is also a component of cofactors (NAD, FAD) and signaling molecules (cAMP).

애플리케이션

Adenine is suitable for use:

• as a component of boron-deficient media to grow yeast in order to assess whether yeast growth is stimulated by boron
• as a food supplement for adult rats to investigate the effects of dietary adenine overload
• as a nucleic acid base supplement in the basal media used to grow anaerobic Bacillus mojavensis and Bacillus subtilis in a study to show that DNA or deoxyribonucleosides are required for the anaerobic growth of these bacteria
• as an additive to investigate the effects of adenine on CH₄ production and on fermentation by ruminal batch cultures from nonlactating Holstein cows
• as a part of adenine diet in rats in a study to identify blood markers for early stages of adenine-induced chronic kidney disease (CKD)

생화학적/생리학적 작용

Adenine is essential for many in vivo and in vitro biochemical processes. Adenine is converted to adenosine with ribose. On phosphorylation, it forms AMP, ADP and ATP. ATP is the energy currency of the cell and is required during cellular metabolism. Adenine is metabolized to is 2,8-dihydroxyadenine, which on accumulation in proximal tubules leads to the induction of chronic kidney disease (CKD) with severe anemia in rats. Adenine based derivatives elicit antiviral functionality against dsDNA viruses and are exploited for generating antiviral scaffolds.

안전성 정보

• 픽토그램: GHS06
• 신호어: Danger
• 유해 및 위험 성명서: H301
• 예방조치 성명서: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Faceshields, Gloves