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모든 사진(1)

Key Documents

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SMB01354

Sigma-Aldrich

Losartan carboxylic acid

≥95% (HPLC)

동의어(들):

EXP3174, 2-Butyl-4-chloro-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid, E-3174, EXP 3174, EXP-3174

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모든 사진(1)

About This Item

실험식(Hill 표기법):
C22H21ClN6O2
CAS Number:
124750-92-1
Molecular Weight:
436.89
MDL number:
MFCD00871928
UNSPSC 코드:
12352106
NACRES:
NA.21

Quality Level

100

분석

≥95% (HPLC)

형태

solid

배송 상태

wet ice

InChI

1S/C22H21ClN6O2/c1-2-3-8-18-24-20(23)19(22(30)31)29(18)13-14-9-11-15(12-10-14)16-6-4-5-7-17(16)21-25-27-28-26-21/h4-7,9-12H,2-3,8,13H2,1H3,(H,30,31)(H,25,26,27,28)

InChI key

ZEUXAIYYDDCIRX-UHFFFAOYSA-N

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일반 설명

Losartan Carboxylic Acid (E-3174) is an active carboxylic acid metabolite of Losartan. Losartan Carboxylic Acid is a potent and selective angiotensin II receptor type 1 (AT1) antagonist.

애플리케이션

Metabolomics research

기타 정보

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픽토그램

Health hazardExclamation mark
GHS08,GHS07

신호어

Danger

유해 및 위험 성명서

H317,H360D,H362

Hazard Classifications

Lact. - Repr. 1B - Skin Sens. 1B

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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시험 성적서(COA)

Lot/Batch Number

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문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Eleni Karatza et al.
Basic & clinical pharmacology & toxicology, 126(3), 193-202 (2019-09-13)
Losartan presents multiple peaks in the concentration-time profile. This characteristic can be attributed to gastric emptying, which is known to significantly affect the disposition of highly soluble and permeable compounds. The aim of this study was to develop a population
A Gromotowicz-Poplawska et al.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 70(3) (2019-10-01)
The aim of the study was to evaluate the effect of an active metabolite of losartan - EXP3174 - on a performed venous thrombus in hypertensive rat. The contribution of coagulation and fibrinolytic systems as well as platelets in the
L L Chang et al.
Journal of medicinal chemistry, 36(17), 2558-2568 (1993-08-20)
A series of 2,4-dihydro-2,4,5-trisubstituted-3H-1,2,4-triazol-3-ones was prepared via several synthetic routes and evaluated as AII receptor antagonists in vitro and in vivo. The preferred compounds contained a [2'-(5-tetrazolyl)biphenyl-4-yl]methyl side chain at N4 and an n-butyl group at C5. A number of

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