PHR1602

Losartan Potassium

Pharmaceutical Secondary Standard; Certified Reference Material

• 동의어(들): Losartan potassium, 2-Butyl-4-chloro-1-{[2′-(1H-tetrazol-5-yl)(1,1′-biphenyl)-4-yl]methyl}-1H-imidazole-5-methanol monopotassium salt, 2-butyl-4-chloro-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]- 1H-Imidazole-5-methanol potassium salt, DuP 753, MK 954, Potassium 5-(4′-((2-butyl-4-chloro-5-(hydroxymethyl)-1H-imidazol-1-yl)methyl)-[1,1′-biphenyl]-2-yl)tetrazol-1-ide
• 실험식(Hill 표기법): C₂₂H₂₂ClKN₆O
• CAS Number: 124750-99-8
• Molecular Weight: 461.00
• Beilstein: 5845770
• MDL number: MFCD02092704
• UNSPSC 코드: 41116107
• PubChem Substance ID: 329823502
• NACRES: NA.24

속성

• Grade: certified reference material; pharmaceutical secondary standard
• Quality Level: 300
• Agency: traceable to BP 867; traceable to Ph. Eur. Y0001062; traceable to USP 1370462
• API family: losartan
• CofA: current certificate can be downloaded
• 포장: pkg of 1 g
• 기술: HPLC: suitable; gas chromatography (GC): suitable
• 응용 분야: pharmaceutical (small molecule)
• 형식: neat
• 저장 온도: 2-30°C
• SMILES string: CCCCc1nc(Cl)c(CO)n1Cc2ccc(cc2)-c3ccccc3-c4nnnn4[K]
• InChI: 1S/C22H22ClN6O.K/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22;/h4-7,9-12,30H,2-3,8,13-14H2,1H3;/q-1;+1
• InChI key: OXCMYAYHXIHQOA-UHFFFAOYSA-N
• 유전자 정보: human ... AGTR1(185)

설명

일반 설명

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Losartan Potassium is a novel class of orally active, non-peptide angiotensin II (type AT₁) receptor antagonist drug that can be used in the remedy of hypertension. It exhibits superior activity than many other peptide receptor antagonist drugs and angiotensin converting enzyme (ACE) inhibitors owing to the high specificity, selectivity, and tolerability.

애플리케이션

Losartan Potassium may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography techniques and spectrophotometric technique.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

생화학적/생리학적 작용

Losartan potassium is an orally available, potent, and selective competitive angiotensin II receptor type 1 (AT1) antagonist. Losartan potassium is used for treatment of hypertension.

orally available, potent, and selective competitive angiotensin II receptor type 1 (AT1) antagonist

분석 메모

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

기타 정보

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

각주

To see an example of a Certificate of Analysis for this material enter LRAC0141 in the slot below. This is an example certificate only and may not be the lot that you receive.

추천 제품

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable