SMB00975

Bisdesethylchloroquine Hydrochloride

• 동의어(들): Bisdesethyl chloroquine hydrochloride, Didesethylchloroquine hydrochloride
• 실험식(Hill 표기법): C₁₄H₁₈ClN₃ · xHCl
• Molecular Weight: 263.77 (free base basis)
• MDL number: MFCD00871854
• NACRES: NA.77

속성

• 분석: ≥95% (HPLC)
• Quality Level: 200
• 형태: solid
• 저장 온도: 2-8°C

설명

일반 설명

Bisdesethylchloroquine is an immediate metabolite of hydroxychloroquine and chloroquine. These are antimalarial drugs used clinically in the treatment of rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and other inflammatory rheumatic diseases. These drugs interfere with lysosomal activity and autophagy, interact with membrane stability and alter signalling pathways and transcriptional activity, which can result in modulation of cytokine production and certain co-stimulatory molecules. Hydroxychloroquine and chloroquine mode(s) of action are still emerging and their metabolism are of great interest. Metabolic Pathway: Cytochrome P450 drug.

애플리케이션

Metabolomics research

기타 정보

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안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302
• 예방조치 성명서: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable