SBR00025

Novobiocin Ready Made Solution

100 mg/mL in water

• 동의어(들): Novobiocin Ready Made Solution
• Linear Formula: C₃₁H₃₅N₂NaO₁₁
• Molecular Weight: 634.61
• UNSPSC 코드: 51286504
• NACRES: NA.76

속성

• 생물학적 소스: microbial
• 분석: ≥90%
• 형태: liquid
• 농도: 100 mg/mL in water
• 색상: faint yellow to dark brown
• 항생제 활성 스펙트럼: Gram-negative bacteria; Gram-positive bacteria; mycobacteria; neoplastics
• 동작 모드: DNA synthesis | interferes; enzyme | inhibits
• 저장 온도: −20°C

설명

일반 설명

Novobiocin, also known as albamycin or cathomycin, is an aminocoumarin antibiotic commonly derived from Streptomyces Sp. It exerts its antibacterial activity by inhibiting Topo II α, which corresponds to bacterial DNA gyrase. It is effective against both gram-positive and gram-negative bacteria and is significant in research involving highly beta-lactam-resistant pneumococcal infections and anti-orthopoxvirus applications. Functioning as a competitive inhibitor in the ATPase reaction catalyzed by GyrB, Novobiocin is employed in microbiology and cell biology research to effectively prevent the growth of bacterial contaminants.

애플리케이션

Novobiocin has been used:

• in cell culture systems to treat mycoplasma contaminations.[3]
• in a research to where it has exhibited anti-cancer effects by inhibition of Hsp90 (heat shock protein)[4],[5]

생화학적/생리학적 작용

Mode of Action: Inhibits DNA synthesis by inhibiting the enzyme Topoisomerase II

Activity spectrum: Active against gram-positive and gram-negative bacteria

특징 및 장점

• Ready available solution reduce the need for preparation time
• Commonly used in Cell Biology and Biochemical applications
• High quality antibiotic suitable for mulitple research applications

제조 메모

Novobiocin Ready Made Solution is light sensitive. Thaw this product at room temperature. It is recommended to avoid repeated freeze thaw cycles of this product. The suggested concentration of Novobiocin for cell culture assays is 50-1000 μg/mL,^,, therefore, it is recommended to dilute the Ready Made Solution 1:100-2000.

기타 정보

For additional information on our range of Biochemicals, please complete this form.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H317
• 예방조치 성명서: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• Hazard Classifications: Skin Sens. 1
• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1