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Key Documents

PHR1804

Supelco

Paroxetine hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

동의어(들):

Paroxetine hydrochloride hemihydrate, (3S-trans)-3-[(1,3-Benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine hydrochloride hemihydrate

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About This Item

실험식(Hill 표기법):
C19H20FNO3 · HCl · .5 H2O
CAS Number:
Molecular Weight:
374.83
MDL number:
UNSPSC 코드:
41116107
PubChem Substance ID:
NACRES:
NA.24

Grade

certified reference material
pharmaceutical secondary standard

Quality Level

Agency

traceable to BP 1024
traceable to Ph. Eur. Y0000281
traceable to USP 1500218

API family

paroxetine

CofA

current certificate can be downloaded

포장

pkg of 500 mg

기술

HPLC: suitable
gas chromatography (GC): suitable

응용 분야

pharmaceutical (small molecule)

형식

neat

저장 온도

2-8°C

SMILES string

O.Cl[H].Fc1ccc(cc1)[C@@H]2CCNC[C@H]2COc3ccc4OCOc4c3

InChI

1S/C19H20FNO3.ClH.H2O/c20-15-3-1-13(2-4-15)17-7-8-21-10-14(17)11-22-16-5-6-18-19(9-16)24-12-23-18;;/h1-6,9,14,17,21H,7-8,10-12H2;1H;1H2/t14-,17-;;/m0../s1

InChI key

QRQSGFFISBKLMZ-YHOFXEKLSA-N

유전자 정보

human ... SLC6A4(6532)

유사한 제품을 찾으십니까? 방문 제품 비교 안내

일반 설명

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Paroxetine hydrochloride, a phenylpiperidine derivative, is a selective serotonin reuptake inhibitor (SSRI) used for its anti-depressant properties. It is used to treat major depression, post-traumatic stress disorder (PTSD), panic disorder, and obsessive-compulsive disorder (OCD) among others.

애플리케이션

This pharmaceutical secondary standard can also be used as follows:

  • Development of a reversed phase high-performance liquid chromatographic (RP-HPLC) method for the determination of paroxetine and clonazepam in pharmaceutical tablet forms
  • High-performance thin-layer chromatographic (HPTLC) determination of paroxetine and clonazepam in pharmaceutical formulations following International Conference on Harmonization (ICH) guidelines
  • Chiral and achiral impurity profiling of paroxetine hydrochloride using supercritical fluid chromatography (SFC) and a chiral stationary phase
  • Determination of seven phosphodiesterase-5 inhibitors and serotonin reuptake inhibitors by HPLC combined with diode array detection (DAD) from tablet dosage forms
  • Separation and estimation of paroxetine from its enantiomeric and diastereomeric impurities by an HPLC method using an amylose-based chiral stationary phase

생화학적/생리학적 작용

Paroxetine hydrochloride hemihydrate is one of the most potent and selective of the selective serotonin reuptake inhibitors (SSRI); antidepressant

분석 메모

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

각주

To see an example of a Certificate of Analysis for this material enter LRAB7850 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

관련 제품

제품 번호
설명
가격

픽토그램

Exclamation markEnvironment

신호어

Warning

유해 및 위험 성명서

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Sens. 1 - STOT SE 3

표적 기관

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


가장 최신 버전 중 하나를 선택하세요:

시험 성적서(COA)

Lot/Batch Number

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이 제품을 이미 가지고 계십니까?

문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Kateryna Murlanova et al.
Journal of affective disorders, 282, 1055-1066 (2021-02-20)
Dominant-submissive relationships depend upon functionality of the neural circuits involving monoaminergic neurotransmission. Behavioral profiles of selectively bred dominant (Dom) and submissive (Sub) mice have been proposed to mimic hyperthymic- or depressive-like temperaments observed in patients with affective disorders. These mice
Jiyoung Lee et al.
Nature, 568(7751), 254-258 (2019-03-08)
Mitochondrial metabolism is an attractive target for cancer therapy1,2. Reprogramming metabolic pathways could improve the ability of metabolic inhibitors to suppress cancers with limited treatment options, such as triple-negative breast cancer (TNBC)1,3. Here we show that BTB and CNC homology1

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