추천 제품
Grade
analytical standard
Quality Level
분석
≥98% (HPLC)
기술
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
응용 분야
forensics and toxicology
pharmaceutical (small molecule)
veterinary
형식
neat
저장 온도
−20°C
SMILES string
NC(=O)N1c2ccccc2C3OC3c4ccccc14
InChI
1S/C15H12N2O2/c16-15(18)17-11-7-3-1-5-9(11)13-14(19-13)10-6-2-4-8-12(10)17/h1-8,13-14H,(H2,16,18)
InChI key
ZRWWEEVEIOGMMT-UHFFFAOYSA-N
유사한 제품을 찾으십니까? 방문 제품 비교 안내
일반 설명
Carbamazepine 10,11-epoxide is a metabolite of the drug carbamazepine.
애플리케이션
Carbamazepine 10,11-epoxide may be used as a test material in the quantification of histone deacetylases(HDAC) inhibition using fluorescent HDAC activity assay.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
생화학적/생리학적 작용
First metabolite of carbamazepine
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
이미 열람한 고객
Ana Fortuna et al.
Analytical and bioanalytical chemistry, 397(4), 1605-1615 (2010-04-20)
For the first time, a simple, selective and accurate high-performance liquid chromatography method with ultraviolet detection was developed and validated to quantify simultaneously three structurally related antiepileptic drugs; carbamazepine, oxcarbazepine, and the recently launched eslicarbazepine acetate and their main metabolites
Sigrid Mennickent et al.
Journal of separation science, 32(9), 1454-1458 (2009-03-31)
An instrumental planar chromatographic (HPTLC) method for quantification of carbamazepine in human serum was developed using liquid-liquid extraction with dichloromethane, fluorescence activation with perchloric acid 60%/ethanol/water (1:1:1, v/v) and fluorescence detection. Planar chromatographic separation was performed on precoated silica gel
Terumitsu Yoshida et al.
Journal of pharmaceutical and biomedical analysis, 41(4), 1386-1390 (2006-04-07)
This study developed a simple method for the simultaneous determination of zonisamide (ZNS), carbamazepine (CBZ) and its active metabolite, carbamazepine-10,11-epoxide (CBZE) in infant serum using reversed-phase high-performance liquid chromatograph (HPLC). The method involves a single-step protein precipitation procedure that uses
Kyoung-Ah Kim et al.
European journal of clinical pharmacology, 61(4), 275-280 (2005-05-26)
Carbamazepine (CBZ) undergoes biotransformation by CYP3A4 and CYP2C8, and glucuronide conjugation. There has been no clear demonstration to reveal the role of glucuronidation in the disposition of CBZ. We evaluated the effect of probenecid, a UDP-glucuronosyltransferase inhibitor, on the pharmacokinetics
Andreas S Beutler et al.
Life sciences, 76(26), 3107-3115 (2005-04-27)
Carbamazepine (CBZ) is a common antiepileptic drug (AED) that acts through multiple mechanisms including blockade and potentiation of cation channels and modulation of neurotransmitter levels. Whether it affects any component of the gene transcription machinery is unknown. Histone deacetylases (HDAC)
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