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주요 문서

C0166000

Calcifediol

European Pharmacopoeia (EP) Reference Standard

동의어(들):

25-Hydroxyvitamin D3 monohydrate, 25-Hydroxycholecalciferol

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About This Item

실험식(Hill 표기법):
C27H44O2 · H2O
CAS Number:
Molecular Weight:
418.65
Beilstein:
4270041
MDL number:
UNSPSC 코드:
41116107
PubChem Substance ID:
NACRES:
NA.24

생물학적 소스

sheep wool (grease)

Grade

pharmaceutical primary standard

Agency

EP

API family

calcifediol

양식

solid

제조업체/상표

EDQM

기술

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

응용 분야

pharmaceutical (small molecule)

형식

neat

SMILES string

[H][C@@]1(CC[C@@]2([H])C(\CCC[C@]12C)=C\C=C3\C[C@@H](O)CCC3=C)[C@H](C)CCCC(C)(C)O

InChI

1S/C27H44O2/c1-19-10-13-23(28)18-22(19)12-11-21-9-7-17-27(5)24(14-15-25(21)27)20(2)8-6-16-26(3,4)29/h11-12,20,23-25,28-29H,1,6-10,13-18H2,2-5H3/b21-11+,22-12-/t20-,23+,24-,25+,27-/m1/s1

InChI key

JWUBBDSIWDLEOM-DTOXIADCSA-N

유전자 정보

human ... VDR(7421)

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관련 카테고리

일반 설명

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.Calcifediol is a biologically active metabolite of vitamin D. It is more hydrophilic and better absorbed in the intestine when compared to ergocalciferol or cholecalciferol due to the high affinity for the vitamin-D-binding protein. The drug is known to treat diseases associated with decreased intestinal absorption and obesity.

애플리케이션

Calcifediol EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

포장

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

기타 정보

Sales restrictions may apply.

픽토그램

Skull and crossbonesHealth hazard

신호어

Danger

유해 및 위험 성명서

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 3 Dermal - Acute Tox. 3 Oral - STOT RE 1 Oral

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


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시험 성적서(COA)

Lot/Batch Number

죄송합니다. 지금은 이 제품에 대한 COA이(가) 온라인에서 제공되지 않습니다.

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문서 라이브러리 방문

Hypovitaminosis D: is it time to consider the use of calcifediol?
Cesareo R, et al.
Nutrients, 11(5), 1016-1016 (2019)
Kristyna Brabnikova-Maresova et al.
Arthritis research & therapy, 16(5), 460-460 (2014-10-05)
Juvenile idiopathic arthritis (JIA) is a disease associated with loss of bone mass, deterioration in bone mass quality and an increased risk of fractures. The objective of this study was to evaluate factors that predict bone mineral density (BMD) alterations
Stuart M Sprague et al.
American journal of nephrology, 40(6), 535-545 (2015-01-13)
Vitamin D insufficiency drives secondary hyperparathyroidism (SHPT) and is associated with increased cardiovascular mortality in patients with chronic kidney disease (CKD). SHPT is poorly addressed by current vitamin D repletion options. The present study evaluated a novel investigational vitamin D
Ting-I Lee et al.
International journal of cardiology, 176(1), 151-157 (2014-07-27)
High free fatty acid with reduced glucose utilization in diabetes mellitus (DM) impairs cardiac function. Peroxisome proliferator-activated receptors (PPARs) modulate myocardial lipid and glucose homeostasis. The active 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) regulates oxidative stress and inflammation, which may play a key
Cécile Meunier et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 989, 54-61 (2015-03-25)
Many methods for routine total plasma/serum 25-hydroxyvitamin D (25OHD) measurements are available from automated immunoassays to the most specific LC-MS/MS techniques. These last ones are nowadays numerous, still perfectible but more powerful than immunoassays in specific illnesses. We presented a

문서

This application shows an Ascentis Express F5 provided rapid resolution of the isobaric vitamin D metabolites. MS detection provides the necessary secondary resolution.

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