90833

3-Carboxy-4-methyl-5-propyl-2-furanpropanoic acid

analytical standard

• 동의어(들): 3-Carboxy-4-methyl-5-propyl-2-furanpropionic acid, CMPF, Propylurofuranic acid
• 실험식(Hill 표기법): C₁₂H₁₆O₅
• CAS Number: 86879-39-2
• Molecular Weight: 240.25
• MDL number: MFCD08436079
• UNSPSC 코드: 12352106
• NACRES: NB.21

속성

• Grade: analytical standard
• Quality Level: 100
• 분석: ≥95.0% (HPLC)
• 유통기한: limited shelf life, expiry date on the label
• 응용 분야: clinical testing
• 형식: neat
• 저장 온도: 2-8°C
• SMILES string: OC(CCC1=C(C(O)=O)C(C)=C(CCC)O1)=O
• InChI: 1S/C12H16O5/c1-3-4-8-7(2)11(12(15)16)9(17-8)5-6-10(13)14/h3-6H2,1-2H3,(H,13,14)(H,15,16)
• InChI key: WMCQWXZMVIETAO-UHFFFAOYSA-N

설명

일반 설명

3-Carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF), a major metabolite of furan fatty acids, is a uremic toxin (UT), excreted into the urine via organic,anion transporters under physiological conditions. It is mostly reported to be accumulated in chronic kidney disease (CKD) patients. Monitoring of CMPF may be important to predict organic anion transporting polypeptide (OATP)1B activity in CKD patients as studies have implicated a decreased trend in (OATP)1B activity in patients with this uremic toxin. It is also found to be in increased concentrations, for patients who progress from prediabetes to type 2 diabetes, patients with renal failure, polyunsaturated fatty acids with high-temperature cooking and subjects who consume fish or fish oil.

애플리케이션

3-Carboxy-4-methyl-5-propyl-2-furanpropanoic acid may be used as an analytical reference standard for the quantification of the analyte in human plasma samples using ultra-high performance liquid chromatography coupled to tandem mass spectrometry (UHPLC–MS/MS).

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3