89802

4-(Dimethylamino)azobenzene-4′-sulfonyl chloride

for HPLC derivatization, LiChropur^™, 98.0-102.0% (AT)

• 동의어(들): 4-(4-Dimethylaminophenylazo)benzenesulfonyl chloride, DABS-Cl, Dabsyl chloride
• Linear Formula: (CH₃)₂NC₆H₄N=NC₆H₄SO₂Cl
• CAS Number: 56512-49-3
• Molecular Weight: 323.80
• Beilstein: 3064095
• EC Number: 260-235-1
• MDL number: MFCD00007444
• UNSPSC 코드: 12352200
• NACRES: NA.22

속성

• Grade: derivatization grade ((HPLC)); for HPLC derivatization
• Quality Level: 100
• 분석: 98.0-102.0% (AT)
• 양식: crystals
• 품질: LiChropur^™
• 기술: HPLC: suitable
• mp: 185 °C (dec.) (lit.)
• SMILES string: CN(C)c1ccc(cc1)\N=N\c2ccc(cc2)S(Cl)(=O)=O
• InChI: 1S/C14H14ClN3O2S/c1-18(2)13-7-3-11(4-8-13)16-17-12-5-9-14(10-6-12)21(15,19)20/h3-10H,1-2H3/b17-16+
• InChI key: VTVWTPGLLAELLI-WUKNDPDISA-N

설명

일반 설명

Amino groups are common to many biological compounds and many amines used in pharmaceuticals. Most of these compounds show weak absorption in direct HPLC analysis with UV-VIS detection. However, strongly absorbing derivatives of amines can be easily detected by HPLC with high sensitivity even when present at low concentrations. Primary and secondary amino groups are usually derivatized as aromatic derivatives by nucleophilic substitution reactions using reagents such as arylsulfonyl chlorides.
4-(Dimethylamino)azobenzene-4′-sulfonyl chloride, a well-known UV-labeling agent, is generally used for the derivatization of N-terminal amino acids, imidazole derivatives, polyamines, etc. prior to their chromatographic determination due to the former′s capacity to covalently bind to the substrates. Its derivatives typically absorb UV radiation between the range of 436-460 nm. This method of derivatization is regarded as superior compared to other methods owing to the simplicity of the procedure, high stability and reproducibility, best resolution of the analytes, etc.

애플리케이션

4-(Dimethylamino)azobenzene-4′-sulfonyl chloride may be used to derivatize biogenic amines, primary amino acids, melamine, and hydroxyproline and proline extracted from various biological samples prior to their determination using high performance liquid chromatography (HPLC) technique to increase their detection sensitivity.

추천 제품

Discover LiChropur^™ reagents ideal for HPLC or LC-MS analysis

법적 정보

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• 픽토그램: GHS05
• 신호어: Danger
• 유해 및 위험 성명서: H314
• 예방조치 성명서: P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Skin Corr. 1B
• Storage Class Code: 8A - Combustible corrosive hazardous materials
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable