89287

Mycophenolic acid

analytical standard

• 동의어(들): 6-(1,3-Dihydro-7-hydroxy-5-methoxy-4-methyl-1-oxoisobenzofuran-6-yl)-4-methyl-4-hexanoic acid, 6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic acid, NSC 129185
• 실험식(Hill 표기법): C₁₇H₂₀O₆
• CAS Number: 24280-93-1
• Molecular Weight: 320.34
• Beilstein: 1295848
• EC Number: 246-119-3
• MDL number: MFCD00036814
• UNSPSC 코드: 41116107
• PubChem Substance ID: 329769720
• NACRES: NA.24

속성

• Grade: analytical standard
• Quality Level: 100
• 분석: ≥98.5% (HPLC)
• 유통기한: limited shelf life, expiry date on the label
• 기술: HPLC: suitable; gas chromatography (GC): suitable
• 불순물: ≤1.0% water
• 응용 분야: forensics and toxicology; pharmaceutical (small molecule)
• 형식: neat
• 저장 온도: 2-8°C
• SMILES string: COc1c(C)c2COC(=O)c2c(O)c1C\C=C(/C)CCC(O)=O
• InChI: 1S/C17H20O6/c1-9(5-7-13(18)19)4-6-11-15(20)14-12(8-23-17(14)21)10(2)16(11)22-3/h4,20H,5-8H2,1-3H3,(H,18,19)/b9-4+
• InChI key: HPNSFSBZBAHARI-RUDMXATFSA-N
• 유전자 정보: human ... IMPDH1(3614) , IMPDH2(3615)

설명

일반 설명

Mycophenolic acid is an active metabolite of the ester prodrug mycophenolate mofetil (MPM), which is prescribed as an immunosuppressant to prevent the organ transplantation rejection and also in the treatment of certain autoimmune diseases.

애플리케이션

Mycophenolic acid (MPA), produced by Penicillum brevi-compactum, is a selective inhibitor of inosine monphosphate dehydrogenase, thus inhibiting DNA synthesis in T and B lymphocytes. It has also been shown to act as an immunosuppressive agent, and as an inducer of monocyte differentiation and apoptosis in human lymphoid and monocytic cell lines. As a selection agent, MPA is used for transfected animal cells expressing the E. Coli gene for xanthine-guanine phosphoribosyl transferase, and is recommended for use at 25μg/mL.

Mycophenolic acid may be used as a reference standard for the determination of the analyte in human plasma by ultra-performance liquid chromatography tandem mass spectrometry.

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

생화학적/생리학적 작용

Mode of Action: This product acts by suppressing the cytokine-induced nitric oxide production, inhibiting early stage biosynthesis of purine nucleotides and as a specific inhibitor of IMP dehydrogenase.

주의사항

As supplied, this product should be stored desiccated at 2-8°C, and is stable for 5 years when stored properly.

제조 메모

Mycophenolic acid is soluble in methanol at 50 mg/mL, yielding a colorless to faint yellow solution, as well as chloroform, dichloromethane, ethanol and .1 N NaOH. After reconstitution, the recommendation is to sterilize via filtration thorugh a 0.22 μm pore-size filter, aliquot, and freeze at -20°C.

안전성 정보

• 픽토그램: GHS08,GHS07,GHS09
• 신호어: Danger
• 유해 및 위험 성명서: H302,H341,H360D,H372,H410
• 예방조치 성명서: P202 - P260 - P264 - P273 - P301 + P312 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Muta. 2 - Repr. 1B - STOT RE 1 Oral
• 표적 기관: Immune system
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable