MMMP2MAG-79K

MILLIPLEX^® Mouse MMP Magnetic Bead Panel 2 - Immunology Multiplex Assay

TIMP Bead-Based Multiplex Assays using the Luminex technology enables the simultaneous analysis of multiple TIMP biomarkers in mouse serum, plasma and cell culture samples.

• UNSPSC 코드: 12161503
• eCl@ss: 32161000
• NACRES: NA.84

속성

• Quality Level: 200
• 종 반응성: mouse
• 제조업체/상표: Milliplex^®
• assay range: standard curve range: 12-50,000 pg/mL; (proMMP-9); standard curve range: 5-20,000 pg/mL; (MMP-12)
• 기술: multiplexing: suitable
• 검출 방법: fluorometric (Luminex xMAP)
• 배송 상태: wet ice

설명

일반 설명

The MMPs (matrix metalloproteinases), a family of zinc proteases responsible for the breakdown of extracellular matrix (ECM), play a key role in normal physiological processes, such as embryonic development and tissue morphogenesis, tissue and bone remodeling, wound healing, and angiogenesis. These processes rely on MMPs′ role in the cleavage of cell surface receptors, the release of apoptotic ligands, cell proliferation and differentiation, and chemokine activity modulation. Similar in structure, MMPs are synthesized and secreted as inactive pro-enzymes that require proteolytic cleavage for activation. This process can be mediated by serine proteases or other MMPs. An increase in MMP expression occurs in response to a wide range of stimuli, including adhesion molecules, growth factors, cytokines, and hormones. Regulation of MMP activity is controlled primarily by TIMPs (tissue inhibitors of metalloproteinases). Therefore, disruption of the MMP/TIMP balance can result in autoimmune disease, arthritis, cardiovascular disease, and tumor growth and metastasis.

MILLIPLEX^® Mouse MMP Bead Panel 2, MMMP2MAG-79K, is a 2 plex kit to be used for the simultaneous quantification of the following analytes in serum/plasma samples: proMMP-9 and MMP-12.

Panel Type: Cytokines/Chemokines

특이성

Cross-reactivity between the antibodies and any of the other analytes in this panel is non-detectable or negligible.

애플리케이션

• Analytes: proMMP-9, MMP-12
• Recommended Sample type: serum or plasma
• Recommended Sample dilution: 1:2
• Assay Run Time: overnight or one day
• Research Category: Inflammation & Immunology

특징 및 장점

Design your multiplex kit by choosing available analytes within this panel.

저장 및 안정성

Recommended storage for kit components is 2 - 8°C.

기타 정보

Sensitivity: See protocol for sensitive’s of individual analytes

법적 정보

MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• 픽토그램: GHS08,GHS05,GHS07,GHS09
• 신호어: Danger
• 유해 및 위험 성명서: H302 + H312 + H332,H317,H318,H373,H411
• 예방조치 성명서: P273 - P280 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338 - P314
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1 - STOT RE 2
• 표적 기관: Respiratory Tract
• Storage Class Code: 10 - Combustible liquids