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Merck
모든 사진(1)

Key Documents

MABC291

Sigma-Aldrich

Anti-PSMA Antibody, clone 3/A12

clone 3/A12, from mouse

동의어(들):

Glutamate carboxypeptidase 2, Cell growth-inhibiting gene 27 protein, Folate hydrolase 1, Folylpoly-gamma-glutamate carboxypeptidase, FGCP, Glutamate carboxypeptidase II, GCPII, Membrane glutamate carboxypeptidase, mGCP, N-acetylated-alpha-linked acidic

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About This Item

UNSPSC 코드:
12352203
eCl@ss:
32160702
NACRES:
NA.41

생물학적 소스

mouse

Quality Level

항체 형태

purified immunoglobulin

항체 생산 유형

primary antibodies

클론

3/A12, monoclonal

종 반응성

human

기술

activity assay: suitable
flow cytometry: suitable
immunofluorescence: suitable
inhibition assay: suitable
western blot: suitable

동형

IgG1κ

NCBI 수납 번호

UniProt 수납 번호

배송 상태

wet ice

타겟 번역 후 변형

unmodified

유전자 정보

human ... FOLH1(2346)

일반 설명

Prostate-specific membrane antigen (PSMA), also known as Glutamate carboxypeptidase II (GCPII), Folate hydrolase 1 (FOLH1), and N-acetylated-alpha-linked acidic dipeptidase I (NAALADase I), is a member of the peptidase M28 family and is involved in prostate tumor progression. It is highly expressed in prostate epithelium and detected in urinary bladder, kidney, testis, ovary, fallopian tube, breast, adrenal gland, liver, esophagus, stomach, small intestine, colon, and brain (at protein level). Mutations in PSMA have been associated with prostate cancer and hyperhomocysteinemia. PSMA may be a possible marker for neurological disorders such as schizophrenia, Alzheimer′s disease, and Huntington disease.

면역원

Recombinant protein corresponding to human PSMA.

애플리케이션

Anti-PSMA Antibody, clone 3/A12 is a highly specific mouse monoclonal antibody, that targets PSMA & has been tested in Flow Cytometry, western blotting, Immunofluorescence, Activity Assay & Inhibition.
Research Category
Apoptosis & Cancer
Western Blotting Analysis: A representative lot from an independent laboratory detected purified PSMA in WB (Elsasser-Beile, U., et al. (2006). Prostate. 66(13):1359-1370.).

Immunofluorescence Analysis: A representative lot from an independent laboratory detected PSMA in LNCaP cells (Elsasser-Beile, U., et al. (2006). Prostate. 66(13):1359-1370.).

Inhibition Assay Analysis (Small-animal PET imaging): A representative lot from an independent laboratory blocked PSMA in mice bearing PSMA-positive C4-2 tumors and negative DU145 tumors (Elsasser-Beile, U., et al. (2009). J Nucl Med. 50(4):606-611.).

Activity Assay Analysis: A representative lot from an independent laboratory was co-internalized with cell adherent PSMA, when PSMA binds to its putative ligand (Liu, J. et al. (2009). Mol Pharm. 6(3):959-970.).

품질

Evaluated by Flow Cytometry in 1X10E6 LNCaP cells.

Flow Cytometry Analysis: 1 µg of this antibody detected PSMA in LNCaP cells.

표적 설명

84 kDa calculated

결합

Replaces: MABN1035

물리적 형태

Format: Purified
Protein G Purified
Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

저장 및 안정성

Stable for 1 year at 2-8°C from date of receipt.

기타 정보

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

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문서 라이브러리 방문

PET imaging of prostate cancer xenografts with a highly specific antibody against the prostate-specific membrane antigen.
Elsasser-Beile, Ursula, et al.
Journal of Nuclear Medicine, 50, 606-611 (2009)
A new generation of monoclonal and recombinant antibodies against cell-adherent prostate specific membrane antigen for diagnostic and therapeutic targeting of prostate cancer.
Elsasser-Beile, Ursula, et al.
Prostate, 66, 1359-1370 (2006)

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