추천 제품
생물학적 소스
mouse
Quality Level
항체 형태
affinity purified immunoglobulin
항체 생산 유형
primary antibodies
클론
14.2Ga, monoclonal
종 반응성
human
제조업체/상표
Chemicon®
기술
flow cytometry: suitable
immunofluorescence: suitable
immunohistochemistry: suitable
동형
IgG2a
배송 상태
wet ice
타겟 번역 후 변형
unmodified
특이성
Reacts specifically with human GD2 ganglioside.
애플리케이션
Anti-Disialoganglioside GD2 Antibody, clone 14G2a detects level of Disialoganglioside GD2 & has been published & validated for use in FC, IF, IH.
Immunohistochemistry (frozen tissue sections)(Cheresh et al., 1986)
Immunofluorescence of cells in culture
Flow cytometry: 1-2 μg per 10E6 cells
Cytotoxicity for GD2 positive cells (Mujoo et al., 1987, 1989)
Optimal working dilutions must be determined by end user.
Immunofluorescence of cells in culture
Flow cytometry: 1-2 μg per 10E6 cells
Cytotoxicity for GD2 positive cells (Mujoo et al., 1987, 1989)
Optimal working dilutions must be determined by end user.
물리적 형태
Cell culture supernatant in 0.02M PB, pH 7.6, 0.25M NaCl containing 0.1% Sodium Azide
Format: Purified
기타 정보
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
법적 정보
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Functional properties and effect on growth suppression of human neuroblastoma tumors by isotype switch variants of monoclonal antiganglioside GD2 antibody 14.18.
Mujoo, K, et al.
Cancer Research, 49, 2857-2861 (1989)
Biosynthesis and expression of the disialoganglioside GD2, a relevant target antigen on small cell lung carcinoma for monoclonal antibody-mediated cytolysis.
Cheresh, D A, et al.
Cancer Research, 46, 5112-5118 (1986)
Patrizia Garbati et al.
Biomedicines, 8(11) (2020-11-07)
To overcome the lack of effective pharmacological treatments for high-risk neuroblastoma (HR-NB), the development of novel in vitro and in vivo models that better recapitulate the disease is required. Here, we used an in vitro multiclonal cell model encompassing NB
Hideki Yoshida et al.
Scientific reports, 10(1), 1199-1199 (2020-01-29)
β-1,4-N-Acetyl-Galactosaminyltransferase 1 (B4GALNT1) encodes the key enzyme B4GALNT1 to generate gangliosides GM2/GD2. GM2/GD2 gangliosides are surface glycolipids mainly found on brain neurons as well as peripheral nerves and skin melanocytes and are reported to exacerbate the malignant potential of melanomas.
Isolation of retinal progenitor cells from post-mortem human tissue and comparison with autologous brain progenitors.
Henry Klassen, Boback Ziaeian, Ivan I Kirov, Michael J Young, Philip H Schwartz
Journal of Neuroscience Research null
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