HAIAB-10K

MILLIPLEX^® Human Autoimmune Autoantibody Panel

Milliplex^®

• UNSPSC 코드: 12161503
• eCl@ss: 32161000
• NACRES: NA.47

속성

• 종 반응성: human
• 제조업체/상표: Milliplex^®
• 기술: multiplexing: suitable
• 검출 방법: fluorometric (Luminex xMAP)

설명

일반 설명

Autoantibody formation is principal to the pathogenesis of a variety of autoimmune diseases. Dysregulated apoptosis and the subsequent defective clearance of cellular debris leads to the exposure of autoantigens and the generation of autoantibodies. The presence of autoantibodies may indicate disease activity, prognosis, and clinical associations related to a variety of autoimmune diseases. These autoimmune diseases include, but are not limited to, Sjögren′s Syndrome, Systemic Lupus Erythematosus, Mixed Connective Tissue Disease, Systemic Sclerosis, CREST syndrome, Polymyositis/Dermatomyositis, Vasculitis, Anti-Phospholipid Syndrome, and various overlap syndromes of these diseases.

MILLIPLEX^® Human Autoimmune Autoantibody Bead Panel is a 20-plex kit to be used for the simultaneous detection and profiling of any or all of the following analytes in serum and plasma samples: Anti-C1q, Anti-Centromere Protein A (CENP-A), Anti-Centromere Protein B (CENP-B), Anti-β 2-Glycoprotein, Anti-Jo-1, Anti-Ku, Anti-Mi-2, Anti-Myeloperoxidase, Anti-Proliferating cell nuclear antigen A (PCNA), Anti-Alanyl-tRNA synthetase (PL-12), Anti-PM/Scl-100, Anti-Proteinase 3, Anti-Ribosomal P, Anti-Ribonucleoprotein (RNP), Anti-RNP/Smith (RNP/Sm), Anti-Scl-70, Anti-Sm, Anti-Sjögren′s Syndrome-related antigen B/La (SSB/La), Anti-Anti-Sjögren′s Syndrome-related antigen A/Ro52 kDa (SSA/Ro52), Anti-Sjögren′s Syndrome-related antigen A/Ro60 kDa (SSA/Ro60). This panel includes 4 assay control beads as part of the base kit format. From our single to multiplex biomarker solutions, we partner with you to design, develop, analytically verify, and build the most comprehensive library available for autoantibody detection.

Panel Type: Immune Response

특이성

Cross Reactivty
Samples were incubated with no antigen, irrelevant antigen, or specific antigen. Incubation with a partcular antigen led to selective abrogation of the reactivity, while reactivity was unaffected by the irrelevant antigen.

애플리케이션

• Analytes: β2-Glycoprotein, C1q, CENP-B (Centromere Protein B), CENP-A (Centromere Protein A), Jo-1, Ku, Mi-2, Myeloperoxidase (MPO), PCNA (Proliferating Cell Nuclear Antigen A), PL-12 (Alanyl-tRNA synthetase), PM/Scl 100, Proteinase 3, RNP (Ribonucleoprotein), RNP/Smith (RNP/Sm), Ribosomal P, Scl-70, Sm, SSB/La (Sjögren′s Syndrome-related antigen B/La), SSA/Ro60 (Sjögren′s Syndrome-related antigen A/Ro60 kDa), SSA/Ro52 (Sjögren′s Syndrome-related antigen A/Ro52 kDa)
• This is a qualitative assay.
• Four assay control beads are included in the base kit.
• Recommended Sample type: serum and plasma.
• Assay Run Time: Overnight
• Research Category: Category Inflammation & Immunology
• Research Subcategory: Autoimmune disease, Inflammation, Immune Response, Immune Disorders

특징 및 장점

Design your multiplex kit by choosing available analytes within this panel.

포장

96 well plate

Everything you need in a single kit.

저장 및 안정성

Recommended storage for kit components is 2 - 8°C.

법적 정보

MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• 픽토그램: GHS07,GHS09
• 신호어: Warning
• 유해 및 위험 성명서: H317,H319,H411
• 예방조치 성명서: P261 - P264 - P273 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Aquatic Chronic 2 - Eye Irrit. 2 - Skin Sens. 1
• Storage Class Code: 12 - Non Combustible Liquids
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable