DPP4-M

DPP IV Inhibitor

• 동의어(들): DPP IV Inhibitor, Dipeptidyl peptidase 4 Inhibitor, Gliptins
• UNSPSC 코드: 41116012
• eCl@ss: 32160405
• NACRES: NC.07

속성

• 양식: solution
• Quality Level: 100
• NCBI 수납 번호: NM_001935.3
• UniProt 수납 번호: P27487
• 유전자 정보: human ... DPP4(1803)

설명

일반 설명

Dipeptidyl peptidase IV (DPP IV), a dimeric type II integral membrane glycoprotein, is a member of the family of prolyl-specific proteases. It is abundantly expressed in the epithelial and nonepithelial tissues. It is highly expressed in the kidney and the colon.

애플리케이션

Research Category
All

생화학적/생리학적 작용

Dipeptidyl peptidase IV (DPP IV) controls insulin-stimulating hormones, glucagon-like peptide (GLP-1), and glucose-dependent insulinotropic polypeptide (GIP). It′s a promising therapeutic target for type 2 diabetes (T2DM). In addition to its catalytic action, DPP-4 also serves as a binding protein and a ligand of extracellular factors. DPP-4 inhibition causes GLP-1 and GIP to have a prolonged activity, hence DPP-4 inhibitors help maintain glucose homeostasis. DPP IV inhibitors can improve glycemic control for a longer period when compared to early oral hypoglycemics.

저장 및 안정성

Upon arrival, store at 4°C. For long-term of more than 2 weeks, store at –20°C.