ABS1036

Anti-FMO3 Antibody

serum, from rabbit

• 동의어(들): Dimethylaniline monooxygenase [N-oxide-forming] 3, Dimethylaniline oxidase 3, FMO form 2, FMO 3, FMO II, Hepatic flavin-containing monooxygenase 3, Trimethylamine monooxygenase
• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• Quality Level: 100
• 항체 형태: serum
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 종 반응성: human
• 종 반응성(상동성에 의해 예측): chimpanzee (based on 100% sequence homology)
• 기술: immunohistochemistry: suitable; western blot: suitable
• NCBI 수납 번호: NP_001002294
• UniProt 수납 번호: P31513
• 배송 상태: dry ice
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... FMO3(2328)

설명

일반 설명

Dimethylaniline monooxygenase [N-oxide-forming] 3 (EC 1.14.13.8; EC 1.14.13.148; UniProt P31513; also known as Dimethylaniline oxidase 3, FMO form 2, FMO 3, FMO II, Hepatic flavin-containing monooxygenase 3, Trimethylamine monooxygenase) is encoded by the FMO3 (also known as FMOII, TMAU) gene (Gene ID 2328) in human. Flavin-containing mono-oxygenases (FMOs) constitute a family of microsomal chemical- and drug-metabolizing enzymes, with FMO3 being a major form in adult mouse and human liver. FMO3 is responsible for N-oxidation of a malodorous metabolite, trimethylamine (TMA), to the non-odorous trimethylamine N-oxide (TMAO). FMO3 mutations cause trimethylaminuria (TMAU or Fish odor syndrome), a rare inherited disorder due to decreased metabolism of dietary-derived TMA. More than 300 single nucleotide polymorphisms of the human FMO3 have been reported and over 40 of these polymorphisms have been linked to TMAU. 17β-estradiol-dependent ERα activation is reported to play a fundamental role in the regulation of FMO3 gene transcription.

면역원

Epitope: Internal (N-terminal half).

Linear peptide corresponding to an internal sequence from the N-terminal half of human FMO3.

애플리케이션

Detect FMO3 using this Anti-FMO3 Antibody validated for use in Western Blotting, Immunohistochemistry.

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected FMO3 in human liver tissue.

Research Category
Signaling

Research Sub Category
Toxicology & Drug Resistance

품질

Evaluated by Western Blotting in human liver microsomal tissue lysate.

Western Blotting Analysis: A 1:500 dilution of this antibody detected FMO3 in 10 µg of human liver microsomal tissue lysate.

표적 설명

~55 kDa observed. 59.96 kDa calculated.

물리적 형태

Rabbit polyclonal serum with 0.05% sodium azide.

Unpurified

저장 및 안정성

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

기타 정보

Concentration: Please refer to lot specific datasheet.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable