추천 제품
생물학적 소스
rabbit
Quality Level
항체 형태
purified immunoglobulin
항체 생산 유형
primary antibodies
클론
polyclonal
종 반응성
rabbit, canine, rat, human, bovine, mouse, pig
제조업체/상표
Chemicon®
기술
ELISA: suitable
flow cytometry: suitable
immunocytochemistry: suitable
immunohistochemistry: suitable (paraffin)
immunoprecipitation (IP): suitable
radioimmunoassay: suitable
western blot: suitable
UniProt 수납 번호
배송 상태
dry ice
타겟 번역 후 변형
unmodified
유전자 정보
human ... CD44(960)
특이성
CD44v10 Approximant 116 kDa)
Recent studies indicate that the expression of CD44 on the cell surface changes profoundly during tumor metastasis, particularly during the progression of various carcinomas. Sequencing analysis reveals that CD44 exists in different forms (at least 15 isoforms have been identified) that are variants of the common or standard hemopoietic form CD44s. Specifically, the human CD44 gene contains 19 exons, out of which 10 exons can potentially be alternatively spliced. In particular, CD44s contains exons 1-15 and exons 15-19. The other exons (e.g. 6-14) are also spliced in a variety of different cells. For example, epithelial cells contain exons 12-14 inserted into the CD44s transcripts. This isoform has been designated as CD44E. Other CD44 variants CD44v) have the same sequences at the two ends of the molecule, but differ in a middle region (with different numbers of additional exons) located on the external side of the cell membrane. It has been suggested that expression of CD44 variants with the additional exon 14 (so-called v10) is responsible for tumor progression and metastasis. In fact, CD44v10 expression has been used as an indicator of metastasis.
Recent studies indicate that the expression of CD44 on the cell surface changes profoundly during tumor metastasis, particularly during the progression of various carcinomas. Sequencing analysis reveals that CD44 exists in different forms (at least 15 isoforms have been identified) that are variants of the common or standard hemopoietic form CD44s. Specifically, the human CD44 gene contains 19 exons, out of which 10 exons can potentially be alternatively spliced. In particular, CD44s contains exons 1-15 and exons 15-19. The other exons (e.g. 6-14) are also spliced in a variety of different cells. For example, epithelial cells contain exons 12-14 inserted into the CD44s transcripts. This isoform has been designated as CD44E. Other CD44 variants CD44v) have the same sequences at the two ends of the molecule, but differ in a middle region (with different numbers of additional exons) located on the external side of the cell membrane. It has been suggested that expression of CD44 variants with the additional exon 14 (so-called v10) is responsible for tumor progression and metastasis. In fact, CD44v10 expression has been used as an indicator of metastasis.
면역원
Epitope: exon v10
Synthetic peptide of human CD44v10
애플리케이션
ELISA: 1:2000
Flow Cytometry: 1:1000
Immunofluorescence: 1:200
Immunohistostaining of paraffin embedded tissue: 1:250
Immunoprecipitation: 1:200
Western Blotting: 1:1000
RIA: 1:5000
Optimal working dilutions must be determined by the end user.
Flow Cytometry: 1:1000
Immunofluorescence: 1:200
Immunohistostaining of paraffin embedded tissue: 1:250
Immunoprecipitation: 1:200
Western Blotting: 1:1000
RIA: 1:5000
Optimal working dilutions must be determined by the end user.
This Anti-CD44v10 Antibody, exon v10 is validated for use in ELISA, FC, IP, RIA, WB, IC, IH(P) for the detection of CD44v10.
결합
Replaces: 04-1123
물리적 형태
Format: Purified
Purified immunoglobulin. Liquid in 10 mM sodium phosphate, 150 mM NaCl with 0.01% sodium azide.
기타 정보
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
법적 정보
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
적합한 제품을 찾을 수 없으신가요?
당사의 제품 선택기 도구.을(를) 시도해 보세요.
Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Qian Guo et al.
The Journal of biological chemistry, 298(11), 102588-102588 (2022-10-16)
Cell adhesion molecule CD44v8-10 is associated with tumor ste0mness and malignancy; however, whether CD44v10 alone confers these properties is unknown. Here, we demonstrated that CD44v10 promotes stemness and chemoresistance of triple-negative breast cancers (TNBCs) individually. Next, we identified that genes
Molecule CD44 variant 10 expression in lymphocytes infiltrating tumour tissues and epithelial cells in patients with colorectal cancer.
B Zalewski, A Stasiak-Barmuta, K Guzinska-Ustymowicz, D Cepowicz, M Gryko
Roczniki Akademii Medycznej w Bialymstoku (1995) null
DNA aptamers against exon v10 of CD44 inhibit breast cancer cell migration.
Iida, J; Clancy, R; Dorchak, J; Somiari, RI; Somiari, S; Cutler, ML; Mural, RJ; Shriver, CD
Testing null
Qian Guo et al.
Oncology reports, 45(4) (2021-03-03)
The cell surface glycoprotein CD44 displays different active statuses; however, it remains unknown whether the activation process of CD44 is critical for tumor development and progression. The aim of the present study was to investigate whether breast cancer (BCa) cells with
Chih-Hung Guo et al.
Marine drugs, 19(4) (2021-04-04)
Fish oil (FO) and selenium (Se) possess antiangiogenic potential in malignant tumors. This study aimed to determine whether combination of FO and Se enhanced treatment efficacy of low-dose antiangiogenic agent Avastin (bevacizumab) in a dose-dependent manner and targeted multiple signaling
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
고객지원팀으로 연락바랍니다.