추천 제품
제품 라인
Novabiochem®
형태
beads
반응 적합성
reaction type: Fmoc solid-phase peptide synthesis
제조업체/상표
Novabiochem®
응용 분야
peptide synthesis
저장 온도
2-30°C
일반 설명
An acid-labile resin for the solid phase immobilization of alcohols [1,2,3,4,5], amines [4, 6,7,8,9,10,11,12], sugars [13], O- and N-linked hydroxylamines [14,15], imidazoles [16] and carboxylic acids [16]. Release of these functionalities is generally achieved using 1-5% TFA in DCM containing 5% TIS. Amines can also be cleaved with 30% HFIP in DCM [4]. This resin, although very acid sensitive, can also be used in peptide synthesis [17].
Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins
Literature references
[1] C. C. Leznoff (1978) Acc. Chem. Res., 11, 327.
[2] C. Chen, et al. (1994) J. Am. Chem. Soc., 116, 2661.
[3] Z. Li & A. Ganesan (1998) Syn. Lett., 405.
[4] P. Athanassopoulos, et al., Poster 316 presented at the 24thEuropean Peptide Symposium, Edinburgh, 1996.
[5] K. Barlos, et al. (1988) Liebigs Ann. Chem., 1079.
[6] K. Barlos, et al. in ′Peptides 1992, Proc. 22nd European Peptide Symposium′, C. H. Schneider & A. N. Eberle (Eds), ESCOM, Leiden,1993, pp. 281.
[7] M. Schuster, et al. (1996) Angew. Chem. Int. Ed. Engl., 35, 1979.
[8] P. Garibay, et al. (1998) Tetrahedron Lett., 39, 2207.
[9] Y. Guan, et al. (2000) J. Comb. Chem., 2, 297.
[10] S. Manku, et al. (2001) J. Org. Chem., 66, 874.
[11] D. Jönsson, et al. (2001) Tetrahedron Lett., 42, 6953.
[12] C. A. Olsen, et al. (2003) Org. Lett., 5, 4183.
[13] F. Peri, et al. (2000) Tetrahedron Lett., 41, 8587.
[14] U. Bauer, et al. (1997) Tetrahedron Lett., 38, 7233.
[15] O. Kinzel, et al. (2003) J. Peptide Sci., 9, 375.
[16] D. P. Matthews, et al. (2000) J Comb. Chem., 2,19.
[17] K. Barlos, et al. (1989) Tetrahedron Lett., 30, 3943.
Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins
Literature references
[1] C. C. Leznoff (1978) Acc. Chem. Res., 11, 327.
[2] C. Chen, et al. (1994) J. Am. Chem. Soc., 116, 2661.
[3] Z. Li & A. Ganesan (1998) Syn. Lett., 405.
[4] P. Athanassopoulos, et al., Poster 316 presented at the 24thEuropean Peptide Symposium, Edinburgh, 1996.
[5] K. Barlos, et al. (1988) Liebigs Ann. Chem., 1079.
[6] K. Barlos, et al. in ′Peptides 1992, Proc. 22nd European Peptide Symposium′, C. H. Schneider & A. N. Eberle (Eds), ESCOM, Leiden,1993, pp. 281.
[7] M. Schuster, et al. (1996) Angew. Chem. Int. Ed. Engl., 35, 1979.
[8] P. Garibay, et al. (1998) Tetrahedron Lett., 39, 2207.
[9] Y. Guan, et al. (2000) J. Comb. Chem., 2, 297.
[10] S. Manku, et al. (2001) J. Org. Chem., 66, 874.
[11] D. Jönsson, et al. (2001) Tetrahedron Lett., 42, 6953.
[12] C. A. Olsen, et al. (2003) Org. Lett., 5, 4183.
[13] F. Peri, et al. (2000) Tetrahedron Lett., 41, 8587.
[14] U. Bauer, et al. (1997) Tetrahedron Lett., 38, 7233.
[15] O. Kinzel, et al. (2003) J. Peptide Sci., 9, 375.
[16] D. P. Matthews, et al. (2000) J Comb. Chem., 2,19.
[17] K. Barlos, et al. (1989) Tetrahedron Lett., 30, 3943.
결합
Replaces: 01-64-0074
분석 메모
Color (visual): white to yellow to beige
Appearance of substance (visual): beads
Loading (determined from the substitution of the Fmoc-Ala-Leu loaded resin): 1.1 - 1.7 mmol/g
Swelling Volume (in CH₂Cl₂): lot specific result
The polymer matrix is copoly (styrene-1 % DVB), 200 - 400 mesh
Appearance of substance (visual): beads
Loading (determined from the substitution of the Fmoc-Ala-Leu loaded resin): 1.1 - 1.7 mmol/g
Swelling Volume (in CH₂Cl₂): lot specific result
The polymer matrix is copoly (styrene-1 % DVB), 200 - 400 mesh
법적 정보
Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
고객지원팀으로 연락바랍니다.