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Merck
모든 사진(1)

Key Documents

8.55010

Sigma-Aldrich

NovaSyn®TGT alcohol resin

Novabiochem®

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About This Item

CAS Number:
UNSPSC 코드:
13111023
NACRES:
NA.22

Quality Level

제품 라인

NovaSyn® TG
Novabiochem®

형태

beads

반응 적합성

reaction type: Fmoc solid-phase peptide synthesis

제조업체/상표

Novabiochem®

응용 분야

peptide synthesis

작용기

alcohol

저장 온도

2-8°C

일반 설명

NovaSyn TGT alcohol resin is derived from TG amino resin by acylation with Bayer′s 4-carboxytrityl linker [1]. Before use the resin must be converted to the chloride form by heating with AcCl [2,3] or SOCl2 [4,5] in toluene. The unstable trityl chloride resin should then be used immediately. Attachment of α-amino acids is free from enantiomerization, making this support ideal for the immobilization of sensitive residues such as Cys and His. Iodine oxidation of peptides containing Cys(Trt) occurs with release of the peptide from the resin. This support is also ideally suited to the synthesis of prolyl peptides as the bulk of the trityl handle prohibits diketopiperazine formation [6].Cleavage of protected peptide acids from this matrix can be effected by treatment with AcOH/MeOH/DCM [1], 0.5% TFA or HFIP [7].

Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins

Literature references

[1] E. Bayer, et al. in ′Peptides, Chemistry, Structure & Biology, Proc. 13th American Peptide Symposium′, R. S. Hodges & J. A. Smith(Eds), ESCOM, Leiden, 1994, pp. 156.
[2] J. M. J. Frechet, et al. (1975) Tetrahedron Lett., 3055.
[3] T. M. Fyles, et al. (1976) Can. J. Chem., 54,935.
[4] A. v. Vliet, et al. in ′Innovation & Perspectives in Solid Phase Synthesis, 2nd International Symposium′, R. Epton (Eds), Intercept UKLtd., Andover, 1992, pp. 475.
[5] A. v. Vliet, et al. in ′Peptides 1992, Proc. 22nd European Peptide Symposium′, C. H. Schneider & A. N. Eberle (Eds), ESCOM, Leiden,1993, pp. 279.
[6] G. Grübler, et al. in ′Innovation & Perspectives in Solid Phase Synthesis, 3rd International Symposium′, R. Epton (Eds), Mayflower Worldwide Ltd., Birmingham, 1994, pp. 517.
[7] R. Bollhagen, et al. (1994) J. Chem. Soc., Chem. Commun., 2559.

결합

Replaces: 01-64-0066

분석 메모

Color (visual): white to yellow to beige
Appearance of substance (visual): beads
Loading (determined from the substitution of the Fmoc-Leu loaded resin): 0.15 - 0.30 mmol/g
Swelling Volume (in CH₂Cl₂): lot specific result
The polymer matrix is NovaSyn TG resin (90 µm).

법적 정보

NOVASYN is a registered trademark of Merck KGaA, Darmstadt, Germany
Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

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문서

Novabiochem® has one of the most extensive ranges of linkers and derivatized resins for Fmoc solid phase peptide synthesis. These resins have varied properties with special protocols for loading and cleaving.

Novabiochem® has one of the most extensive ranges of linkers and derivatized resins for Fmoc solid phase peptide synthesis. These resins have varied properties with special protocols for loading and cleaving.

자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..

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