8.51005

DSC

N,N′-Disuccinimidyl carbonate Novabiochem^®

• 동의어(들): DSC, N,N′-Disuccinimidyl carbonate, Di-(N-Succinimidyl)carbonate
• 실험식(Hill 표기법): C₉H₈N₂O₇
• CAS Number: 74124-79-1
• Molecular Weight: 256.17
• MDL number: MFCD00009767
• UNSPSC 코드: 12352108
• EC 인덱스 번호: 277-730-3

속성

• Quality Level: 200
• 제품 라인: Novabiochem^®
• 분석: ≥99.0% (HPLC)
• 형태: powder
• 반응 적합성: reaction type: Coupling Reactions
• 제조업체/상표: Novabiochem^®
• mp: 188-191 °C
• 응용 분야: peptide synthesis
• 저장 온도: 2-8°C
• InChI: 1S/C9H8N2O7/c12-5-1-2-6(13)10(5)17-9(16)18-11-7(14)3-4-8(11)15/h1-4H2
• InChI key: PFYXSUNOLOJMDX-UHFFFAOYSA-N

설명

일반 설명

A convenient reagent for the synthesis of N-succinimidyl esters of N-protected amino acids ^[1,2,3,4].

Associated Protocols and Technical Articles
Guide to Selection of Coupling Reagents

Literature references

^[1] H. Ogura, et al. (1979) Tetrahedron Lett., 20, 4745.
^[2] H. Ogura, et al. (1981) Tetrahedron Lett., 22, 4817.
^[3] K. Takeda, et al. (1982) Synth. Commun., 12, 213.
^[4] K. Takeda, et al. (1983) TetrahedronLett., 24, 4569.

애플리케이션

• Utilization in solid-phase peptide synthesis: Discusses the role of N,N′-disuccinimidyl carbonate in solid-phase peptide synthesis, providing insights into its effectiveness in enhancing coupling reactions (Meschaninova et al., 2019).
• Surface functionalization of polymeric materials: This article explores the application of N,N′-disuccinimidyl carbonate in the surface functionalization of polymers to improve their biocompatibility and interaction with biological molecules (Yakufu et al., 2020).
• Development of affinity chromatography technologies: Details the use of N,N′-disuccinimidyl carbonate in the development of novel affinity chromatography approaches for protein purification (Hinamoto et al., 2023).
• Enhancement of polymer properties: Investigates how N,N′-disuccinimidyl carbonate can be used to modify polymer surfaces to enhance their properties, such as increased hydrophilicity and reactivity (Swar et al., 2020).

결합

Replaces: 01-62-0006

분석 메모

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Assay (HPLC, area%): ≥ 99.0 % (a/a)
Water (K. F.): ≤ 0.50 %
Identity (IR): passes test

법적 정보

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• 픽토그램: GHS07,GHS08
• 신호어: Warning
• 유해 및 위험 성명서: H302 - H319 - H373
• 예방조치 성명서: P260 - P264 - P270 - P301 + P312 - P305 + P351 + P338 - P314
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - STOT RE 2 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable