8.22288

Periodic acid

for synthesis

• 동의어(들): Periodic acid
• 실험식(Hill 표기법): H₅IO₆
• CAS Number: 10450-60-9
• Molecular Weight: 227.94
• MDL number: MFCD00011344
• UNSPSC 코드: 12352301
• EC 인덱스 번호: 233-937-0
• NACRES: NA.22

속성

• Quality Level: 200
• 분석: ≥98% (iodometric)
• 양식: solid
• 반응 적합성: reagent type: oxidant
• pH: 1.2 (20 °C, 100 g/L in H₂O)
• mp: 122 °C
• solubility: ethanol: soluble at 20 °C; water: soluble at 20 °C
• 벌크 밀도: 1400 kg/m³
• 저장 온도: 15-25°C
• SMILES string: [I](=O)(O)(O)(O)(O)O
• InChI: 1S/H5IO6/c2-1(3,4,5,6)7/h(H5,2,3,4,5,6,7)
• InChI key: TWLXDPFBEPBAQB-UHFFFAOYSA-N

설명

애플리케이션

Periodic acid can be used as a reagent for the oxidative cleavage of 1,2 diols to ketones or aldehydes, and epoxides to aldehydes. It is also used in the oxidative cleavage of various protecting groups such as acetonide, tetrahydropyranyl ether (THP), ethoxyethyl acetals, cyclic acetals, dithioacetals, and oxathioacetals.
It can also be used:

• In the selective N-nitrosation of secondary amines in the presence of sodium nitrite, and wet silica gel.
• As a stoichiometric oxidant with chromium (IV) acetate for the oxidation of tertiary C−H bonds to tertiary alcohols.
• In combination with chromium oxide to oxidize primary alcohols to carboxylic acids; alkylbenzenes to benzoic acids; and cyclic benzyl ethers to the corresponding lactones.
• In the iodination of bulky polyalkyl benzenes in the presence of iodine.
• In the oxidative coupling of polycyclic aromatic hydrocarbons in the presence of aqueous acetic acid.
• In the selective oxidation of sulfides to sulfoxides using FeCl₃ as a catalyst.

분석 메모

Assay (iodometric): ≥ 98.0 %
Melting range (lower value): ≥ 124 °C
Melting range (upper value): ≤ 129 °C

안전성 정보

• 픽토그램: GHS03,GHS05,GHS08,GHS09
• 신호어: Danger
• 유해 및 위험 성명서: H271 - H314 - H372 - H410
• 예방조치 성명서: P210 - P260 - P273 - P280 - P303 + P361 + P353 - P305 + P351 + P338
• Hazard Classifications: Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Ox. Sol. 1 - Skin Corr. 1B - STOT RE 1 Oral
• 표적 기관: Thyroid
• Storage Class Code: 5.1A - Strongly oxidizing hazardous materials
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable