8.17058

Maleic acid

EMPROVE^® ESSENTIAL, Ph. Eur., NF

• 동의어(들): cis-Butenedioic acid, Toxilic acid
• Linear Formula: HO₂CCH=CHCO₂H
• CAS Number: 110-16-7
• Molecular Weight: 116.07
• Beilstein: 605762
• MDL number: MFCD00063177
• UNSPSC 코드: 12352106
• EC 인덱스 번호: 203-742-5

속성

• Agency: NF; Ph. Eur.
• Quality Level: 500
• vapor pressure: <0.1 hPa ( 20 °C)
• 제품 라인: EMPROVE^® ESSENTIAL
• 분석: 99.0-101.0% substance (anhydrous) basis
• 형태: solid
• 효능: 708 mg/kg LD₅₀, oral (Rat); 1560 mg/kg LD₅₀, skin (Rabbit)
• 기술: API processing | cocrystal formation: suitable; API processing | salt formation: suitable
• pH: 1.3 (20 °C, 100 g/L in H₂O)
• mp: 130-135 °C (lit.)
• solubility: 478.8 g/L
• density: 1.59 g/mL at 25 °C (lit.)
• 양이온 미량물: Fe: ≤5 ppm; V: ≤1 ppm; heavy metals (as Pb): ≤10 ppm
• 응용 분야: liquid formulation; pharmaceutical; semi-solid formulation; solid formulation
• 저장 온도: 15-25°C
• SMILES string: OC(=O)\C=C/C(O)=O
• InChI: 1S/C4H4O4/c5-3(6)1-2-4(7)8/h1-2H,(H,5,6)(H,7,8)/b2-1-
• InChI key: VZCYOOQTPOCHFL-UPHRSURJSA-N

설명

일반 설명

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our EMPROVE^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

애플리케이션

Maleic acid is typically used as pH adjuster or buffer agent in pharmaceutical formulations. Maleic acid Emprove^® Essential is mainly used in highly regulated pharmaceutical applications.

법적 정보

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• 픽토그램: GHS05,GHS07
• 신호어: Danger
• 유해 및 위험 성명서: H302 + H312,H314,H317,H335
• 예방조치 성명서: P260 - P271 - P280 - P301 + P312 - P303 + P361 + P353 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Oral - Eye Dam. 1 - Skin Corr. 1 - Skin Sens. 1 - STOT SE 3
• 표적 기관: Respiratory system
• Storage Class Code: 8A - Combustible corrosive hazardous materials
• WGK: WGK 1