8.00907

N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride

for peptide synthesis

• 동의어(들): N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride
• 실험식(Hill 표기법): C₈H₁₇N₃ · xHCl
• CAS Number: 25952-53-8
• Molecular Weight: 155.24 (free base basis)
• MDL number: MFCD00012503
• UNSPSC 코드: 12352107
• EC 인덱스 번호: 247-361-2
• NACRES: NA.22

속성

• product name: N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride, for synthesis
• Quality Level: 200
• 형태: solid
• 반응 적합성: reaction type: Coupling Reactions
• mp: 110-115 °C
• 응용 분야: peptide synthesis
• 저장 온도: −20°C (−15°C to −25°C)
• InChI: 1S/C8H17N3.ClH/c1-4-11(8-9)7-5-6-10(2)3;/h4-7H2,1-3H3;1H
• InChI key: FDXPUDRRFDHONO-UHFFFAOYSA-N

설명

일반 설명

N-(3-Dimethylaminopropyl)-N-ethylcarbodiimide hydrochloride, also known as EDAC HCl or WSC, is a water-soluble condensing reagent. EDAC HCl is generally used to couple carboxylic acids with amines to form amides. The by-product urea is water-soluble and can be removed from immiscible reaction milieux by extraction with water. It is principally utilized in solution-phase peptide synthesis and as a zero-length crosslinker for protein modification.

애플리케이션

N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride (EDC hydrochloride) can be used as:

• A water-soluble carbodiimide to facilitate peptide coupling reactions in alcohols.
• A coupling agent along with HOBt to synthesize poly(glutamic acid) (PGA) polypeptides for the creation of non-fouling polypeptides that could be useful in a variety of biomedical applications.
• A coupling reagent for the efficient synthesis of teriflunomide at the industrial scale.

안전성 정보

• 픽토그램: GHS06,GHS08,GHS09
• 신호어: Danger
• 유해 및 위험 성명서: H302 - H311 - H315 - H317 - H373 - H410
• 예방조치 성명서: P260 - P273 - P280 - P301 + P312 - P302 + P352 + P312 - P314
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT RE 2 Oral
• Storage Class Code: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable