콘텐츠로 건너뛰기
Merck
모든 사진(1)

주요 문서

614310

Sigma-Aldrich

TLR3/dsRNA Complex Inhibitor

≥99% (HPLC), solid, TLR3/dsRNA complex inhibitor, Calbiochem®

동의어(들):

TLR3/dsRNA Complex Inhibitor, ( R)-2-(3-Chloro-6-fluorobenzo[b]thiophene-2-carboxamido)-3-phenylpropanoic acid, Toll-Like Receptor 3/Double Strand RNA Complex Inhibitor, (R)-2-(3-Chloro-6-fluorobenzo[b]thiophene-2-carboxamido)-3-phenylpropanoic acid, Toll-Like Receptor 3/Double Strand RNA Complex Inhibitor

로그인조직 및 계약 가격 보기
모든 사진(1)

About This Item

실험식(Hill 표기법):
C18H13ClFNO3S
Molecular Weight:
377.82
UNSPSC 코드:
12352200
NACRES:
NA.28

제품명

TLR3/dsRNA Complex Inhibitor, The TLR3/dsRNA Complex Inhibitor blocks dsRNA binding to TLR3.

Quality Level

100

분석

≥99% (HPLC)

양식

solid

제조업체/상표

Calbiochem®

저장 조건

OK to freeze
protect from light

색상

white

solubility

DMSO: 50 mg/mL

배송 상태

wet ice

저장 온도

2-8°C

일반 설명

A thiophenecarboxamidopropionate compound that acts as a direct, competitive and high affinity inhibitor of dsRNA binding to TLR3 (Ki = 2.96 µM; Kd = 19 nM for dsRNA binding to TLR3) and selectively antagonizes stimulated TLR3 signaling without affecting TLR1/2, TLR2/6, TLR4 and TLR7 pathways. Shown to efficiently repress TNF-α and IL-1β (IC90 = 27 µM) and NO production (IC50 = 3.44 µM) in Poly(I:C)-induced RAW 264.7 macrophages. Exhibits minimal cytotoxicity (IC50 >>100 µM in RAW 264.7 cells) and is weakly active against a panel of 12-representative kinases and 4-cytochrome enzymes (in vitro assays).

포장

Packaged under inert gas

경고

Toxicity: Standard Handling (A)

기타 정보

Cheng, K., et al. 2011. J. Am. Chem. Soc.133, 3764.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

이 제품을 이미 가지고 계십니까?

문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Tshifhiwa Magoro et al.
The Journal of biological chemistry, 294(40), 14591-14602 (2019-08-04)
Zika virus (ZIKV)3 is an enveloped, single-stranded, positive-sense RNA virus of the Flaviviridae family that has emerged as a public health threat because of its global transmission and link to microcephaly. Currently there is no vaccine for this virus. Conversion
Jing-Hua Yang et al.
Research and reports in urology, 14, 399-414 (2022-11-24)
Growing evidence suggests that ischemia provokes detrusor overactivity and degenerative responses in the bladder. Underlying mechanisms appear to involve modification of smooth muscle contractile rudiments by hypoxia, redox, cellular stress and cell survival signaling. Downstream pathways of cellular stress and
Tingxuan Gu et al.
Frontiers in immunology, 11, 621441-621441 (2021-02-16)
Although COVID-19 has become a major challenge to global health, there are currently no efficacious agents for effective treatment. Cytokine storm syndrome (CSS) can lead to acute respiratory distress syndrome (ARDS), which contributes to most COVID-19 mortalities. Research points to

자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..

고객지원팀으로 연락바랍니다.