5.32177

Tdp1 Inhibitor, CD00509

• 동의어(들): Tdp1 Inhibitor, CD00509, Tyrosyl-DNA phosphodiesterase 1 Inhibitor
• 실험식(Hill 표기법): C₉H₆N₂O₃S
• CAS Number: 27430-18-8
• Molecular Weight: 222.22
• MDL number: MFCD00020968
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• 분석: ≥97% (HPLC)
• Quality Level: 100
• 양식: powder
• 효능: 710 nM IC₅₀
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: yellow
• solubility: DMSO: soluble
• 저장 온도: 2-8°C
• SMILES string: S=C1NC(=O)C(=Cc2[o]ccc2)C(=O)N1
• InChI: 1S/C9H6N2O3S/c12-7-6(4-5-2-1-3-14-5)8(13)11-9(15)10-7/h1-4H,(H2,10,11,12,13,15)
• InChI key: VQRARDATQWRHGF-UHFFFAOYSA-N

설명

일반 설명

A cell permeable alkylidene barbiturate analog that acts as a potent and specific inhibitor of tyrosyl-DNA phosphodiesterase 1 (Tdp1; IC₅₀ = 710 nM) and increases the number of g-H2AX foci in MCF-7 cells. Shown to sensitize MCF-7 cells to camptothecin (CPT), increase DNA breaks, and reduce cell proliferation. However, it does not affect the viability of normal mammary epithelial cells up to 10 µM levels. Synergistically reduces cell proliferation and induces apoptosis in MCF-7 cells when combined with Rucaparib, a PARP-1 inhibitor.

생화학적/생리학적 작용

Cell permeable: yes

Primary Target
Tdp1

경고

Toxicity: Standard Handling (A)

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

기타 정보

Dean, R.A., et al. 2014. J. Biolmol. Screen.19, 1372.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable